1.
Hepatotoxicity caused by Garcinia cambogia.
Mas Ordeig, A, Bordón García, N
Gastroenterologia y hepatologia. 2020;(3):134-135
2.
Obesity: When to consider medication.
Saunders, KH, Shukla, AP, Igel, LI, Aronne, LJ
The Journal of family practice. 2017;(10):608-616
Abstract
These 4 cases illustrate how weight loss drugs--including the 4 newest--can be integrated into a treatment plan that includes diet, exercise, and behavior modification.
3.
Drug-induced liver injury due to "natural products" used for weight loss: a case report.
Tarantino, G, Pezzullo, MG, di Minno, MN, Milone, F, Pezzullo, LS, Milone, M, Capone, D
World journal of gastroenterology. 2009;(19):2414-7
Abstract
Taking herbal-extracts to lose weight is an underestimated health hazard. Often, these products contain active agents that can cause acute liver damage. In this case report, a 22-year-old female patient, who presented with a feature of cholestatic syndrome, was so sure that the "natural products" were not dangerous that she did not inform her physicians that she had taken them, making their task that much more challenging. Clinical presentation mimicked acute cholecystitis and the patient underwent a cholecystectomy. Surgery was without any consequences and complications, although it did not completely cure the illness. She later admitted to having taken herbal remedies and this led to the correct diagnosis of phytotherapy-related hepatotoxicity and a successful therapeutic approach. The true incidence of phytotherapy-related hepatotoxicity and its pathogenic mechanisms are largely unknown. It is important to increase the awareness of both clinicians and patients about the potential dangers of herbal remedies.
4.
Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements.
Dara, L, Hewett, J, Lim, JK
World journal of gastroenterology. 2008;(45):6999-7004
Abstract
Dietary supplements represent an increasingly common source of drug-induced liver injury. Hydroxycut is a popular weight loss supplement which has previously been linked to hepatotoxicity, although the individual chemical components underlying liver injury remain poorly understood. We report two cases of acute hepatitis in the setting of Hydroxycut exposure and describe possible mechanisms of liver injury. We also comprehensively review and summarize the existing literature on commonly used weight loss supplements, and their individual components which have demonstrated potential for liver toxicity. An increased effort to screen for and educate patients and physicians about supplement-associated hepatotoxicity is warranted.
5.
Obesity in transplant patients: case report showing interference of orlistat with absorption of cyclosporine and review of literature.
Barbaro, D, Orsini, P, Pallini, S, Piazza, F, Pasquini, C
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. 2002;(2):124-6
Abstract
OBJECTIVE To report a case of an obese patient who had undergone renal transplantation and who had subtherapeutic levels of serum cyclosporine after treatment with orlistat. METHODS The clinical and laboratory findings are presented, and the few cases reported in the literature are reviewed. RESULTS A 29-year-old woman had subtherapeutic plasma levels of cyclosporine after orlistat treatment (360 mg/day) was initiated. The subtherapeutic levels persisted even though orlistat was administered the recommended 2 hours before ingestion of cyclosporine and even though the dosage of orlistat was decreased to only 240 mg/day. Because an increase of body weight is common after organ transplantation, treatment with orlistat has been used. In such patients, however, six cases of reduced therapeutic plasma levels of cyclosporine have been reported. Although a drug-drug interaction has been suggested, this case suggests that the decreased plasma cyclosporine levels are due to reduced absorption of fats rather than a drug-drug interaction. Because this patient was unable to adhere to a low-fat diet, she experienced severe diarrhea, a factor that may have dramatically diminished the absorption of cyclosporine. CONCLUSION Adherence to a low-fat diet should be strongly recommended if orlistat is prescribed to patients taking cyclosporine. Moreover, strict surveillance of the plasma concentration of cyclosporine is important.