1.
[A Phd completed 4. Interactions between root canal irrigants, sealers and dentin].
Neelakantan, P, Shemesh, H, Wesselink, P
Nederlands tijdschrift voor tandheelkunde. 2016;(9):425-7
Abstract
In the field of endodontology, antibacterial activity of irrigants has been investigated many times. The influence of these solutions on the bonding of root canal sealers, however, has hardly been studied. The objective of this doctoral research was to determine the interactions between root canal sealers and root dentin, and to determine the influence of irrigants on these interactions. The various studies revealed that irrigants have an influence on the bonding of sealers based on epoxy resin, calcium hydroxide, silicones and calcium silicate. In the case of a sealer based on epoxy resin (AH Plus), the irrigation protocol had an influence on the bond strength (adhesion) on dentin, by means of which the seal was also improved. The results of this research produced better insights into the mechanisms at play in the adhesive properties of root canal sealers. Eventually, this might result in improved treatment outcomes of root canal treatments.
2.
[Updates on rickets and osteomalacia. dental diseases in rickets].
Kubota, T
Clinical calcium. 2013;(10):1497-502
Abstract
Rickets is characterized by mineralization defect in bone and cartilage. X-linked hypophosphatemic rickets (XLH) is the most common form of inherited rickets. Mineralization defect is observed in dentin as well as in bone and cartilage in XLH. The dominant feature is the occurrence of infectious periradicular abscesses on deciduous and permanent teeth, not associated with trauma or decay. Dental care including the maintenance of good oral hygiene and periodical examinations should be performed. A preventive sealing of occlusal surfaces can be considered. Endodontic treatment or extraction are carried out in the presence of periradicular abscesses. Further studies are necessary for elucidating mechanisms of dentin mineralization defect and the occurrence of periradicular abscesses and for developing preventive and curative measures in XLH.
3.
Tooth dentin defects reflect genetic disorders affecting bone mineralization.
Opsahl Vital, S, Gaucher, C, Bardet, C, Rowe, PS, George, A, Linglart, A, Chaussain, C
Bone. 2012;(4):989-97
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Abstract
Several genetic disorders affecting bone mineralization may manifest during dentin mineralization. Dentin and bone are similar in several aspects, especially pertaining to the composition of the extracellular matrix (ECM) which is secreted by well-differentiated odontoblasts and osteoblasts, respectively. However, unlike bone, dentin is not remodelled and is not involved in the regulation of calcium and phosphate metabolism. In contrast to bone, teeth are accessible tissues with the shedding of deciduous teeth and the extractions of premolars and third molars for orthodontic treatment. The feasibility of obtaining dentin makes this a good model to study biomineralization in physiological and pathological conditions. In this review, we focus on two genetic diseases that disrupt both bone and dentin mineralization. Hypophosphatemic rickets is related to abnormal secretory proteins involved in the ECM organization of both bone and dentin, as well as in the calcium and phosphate metabolism. Osteogenesis imperfecta affects proteins involved in the local organization of the ECM. In addition, dentin examination permits evaluation of the effects of the systemic treatment prescribed to hypophosphatemic patients during growth. In conclusion, dentin constitutes a valuable tool for better understanding of the pathological processes affecting biomineralization.