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Dietary Approaches to Cancer Therapy.
Tajan, M, Vousden, KH
Cancer cell. 2020;(6):767-785
Abstract
The concept that dietary changes could improve the response to cancer therapy is extremely attractive to many patients, who are highly motivated to take control of at least some aspect of their treatment. Growing insight into cancer metabolism is highlighting the importance of nutrient supply to tumor development and therapeutic response. Cancers show diverse metabolic requirements, influenced by factors such as tissue of origin, microenvironment, and genetics. Dietary modulation will therefore need to be matched to the specific characteristics of both cancers and treatment, a precision approach requiring a detailed understanding of the mechanisms that determine the metabolic vulnerabilities of each cancer.
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Maternal Prenatal Exposures in Pregnancy and Autism Spectrum Disorder: An Insight into the Epigenetics of Drugs and Diet as Key Environmental Influences.
Bastaki, KN, Alwan, S, Zahir, FR
Advances in neurobiology. 2020;:143-162
Abstract
Autism spectrum disorder (ASD) is a rapidly growing global pandemic that affects an estimated 1 in 59-68 children. It is a complex disease with both genetic and environmental etiologies. Due to the rapid increase in the incidence of ASD, environmental causes for ASD are gaining attention. Efforts to probe several environmental exposures that could contribute to causing ASD are underway. In this regard, this chapter is directed towards understanding prenatal exposure to key environmental factors i.e., drugs and dietary nutrients that may act via the same molecular pathway - epigenetics as a potential etiological factor for ASD. Epigenetic regulation is a molecular mechanism known to be a significant contributor to neurodevelopmental disorders. It also offers a means to explain how environmental exposures can impact genetics. We discuss the impact of maternal exposures to certain drugs, and dietary intake, on the developing fetus during pregnancy. Maternal Exposure to some drugs during gestation are associated with a higher risk of ASD, while exposure to other dietary compounds may offer promise to rescue epigenetic regulatory insults related to ASD. However, more work in this important area is still required, nevertheless preliminary research already has important implications in the understanding, prevention and treatment of ASD.
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3.
Assessment of energy expenditure: are calories measured differently for different diets?
Sanchez-Delgado, G, Ravussin, E
Current opinion in clinical nutrition and metabolic care. 2020;(5):312-318
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Abstract
PURPOSE OF REVIEW The prevalence and burden of obesity has reached alarming levels. The assessment of human energy expenditure enables the identification of obesity-prone and obesity-resistant individuals and helps to explain the short and long-term success of weight loss treatments. In this review, we describe the state-of-the-art methods used in the assessment of human energy expenditure and the impact of dietary intake on the interpretation of the data. RECENT FINDINGS The reference techniques to assess energy expenditure in humans have not significantly changed during the last century. Today, indirect calorimetry, either using a metabolic chamber or a metabolic cart, is the favored method to assess human energy expenditure and is the only method enabling the assessment of macronutrient oxidation. The doubly labeled water method however provides accurate assessment of human energy expenditure under free living conditions. SUMMARY Although energy expenditure and macronutrient oxidation can be assessed by simple calculations from oxygen consumption and carbon dioxide production, these calculations can provide erroneous results or require corrections and/or more complex interpretation when several biochemical pathways are simultaneously engaged. Such physiological mechanisms are often elicited by dietary interventions including, among other, gluconeogenesis, lipogenesis, ketogenesis, alcohol oxidation and under or overfeeding.
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Africa's Changing Food Environments and Nutritional Effects on Adults and Children.
Demmler, KM, Qaim, M
World review of nutrition and dietetics. 2020;:31-41
Abstract
Many low- and middle-income countries (LMICs) are experiencing profound changes in food environments, including a rapid growth of supermarkets and other modern retailers. Changing food environments can influence people's diets, nutrition, and health. While in many LMICs, undernutrition and micronutrient deficiencies are still widespread, problems of overweight, obesity, and related non-communicable diseases are also massively on the rise. Supermarkets seem to contribute to overweight and obesity among adults, but effects on children and adolescents could possibly be different. Here, we review the available evidence about the implications of supermarkets for people's diets, nutrition, and health. Particular emphasis is placed on recent studies from urban Kenya that used panel data and differencing techniques to identify causal effects on different age cohorts. The results from Kenya show that shopping in supermarkets contributes to higher consumption of processed and highly processed foods and lower consumption of unprocessed foods. These dietary changes lead to significant increases in the body mass index and the probability of being overweight/obese and pre-diabetic among adults. For children, the same increases in overweight are not observed. Instead, supermarket shopping increases child height-for-age Z-scores. Despite higher food processing levels, supermarkets enhance food variety and dietary diversity in the relatively poor households. The results confirm that the growth of supermarkets affects adult and child nutrition differently; while the effects on adults are negative, the effects on children are positive, especially in the Kenyan context where child undernutrition is still widespread. Better understanding the effects of changing food environments on different age cohorts and in different contexts is important to design strategies that can help to make food choices in LMICs healthier. More research in different geographical settings will be useful.
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The Influence of Diet Interventions Using Whole, Plant Food on the Gut Microbiome: A Narrative Review.
Willis, HJ, Slavin, JL
Journal of the Academy of Nutrition and Dietetics. 2020;(4):608-623
Abstract
Dietary intake is a key determinant of gastrointestinal microbiota composition. Studies have considered the relationship between gut microbiota and dietary patterns. It is likely that certain plant foods that contain fiber and other bioactive matter may be more likely to drive microbial changes than others; however, study design and other factors can make interpretation of the literature difficult. Fifteen well-controlled, well-defined diet interventions published between 2008 and 2018 using whole, plant foods were evaluated for their influence on gut microbiota. There was limited effect on microbial diversity across studies and modest microbial changes were noted in 10 of 15 studies. More research is needed before specific plant foods can be recommended to improve gut microbiota and ultimately health. Methodologic considerations for future diet and microbiome studies are discussed. Additional research to better understand how specific whole, plant foods influence microbe composition, functionality, and metabolite production is needed, as are mechanistic studies linking diet-induced gut microbe changes to health.
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Bisphenol A and Phthalates in Diet: An Emerging Link with Pregnancy Complications.
Filardi, T, Panimolle, F, Lenzi, A, Morano, S
Nutrients. 2020;(2)
Abstract
Endocrine-disrupting chemicals (EDCs) are exogenous substances that are able to interfere with hormone action, likely contributing to the development of several endocrine and metabolic diseases. Among them, Bisphenol A (BPA) and phthalates contaminate food and water and have been largely studied as obesogenic agents. They might contribute to weight gain, insulin resistance and pancreatic β-cell dysfunction in pregnancy, potentially playing a role in the development of pregnancy complications, such as gestational diabetes mellitus (GDM), and adverse outcomes. Pregnancy and childhood are sensitive windows of susceptibility, and, although with not univocal results, preclinical and clinical studies have suggested that exposure to BPA and phthalates at these stages of life might have an impact on the development of metabolic diseases even many years later. The molecular mechanisms underlying this association are largely unknown, but adipocyte and pancreatic β-cell dysfunction are suspected to be involved. Remarkably, transgenerational damage has been observed, which might be explained by epigenetic changes. Further research is needed to address knowledge gaps and to provide preventive measure to limit health risks connected with exposure to EDCs.
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Management of Irritable Bowel Syndrome: Physician-Dietitian Collaboration.
Ireton-Jones, C, Weisberg, MF
Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition. 2020;(5):826-834
Abstract
Irritable bowel syndrome (IBS) affects 10%-15% of adults in the United States and 12% of the worldwide population. Gastroenterologists as well as primary care practitioners are likely to be the first resource for patients with gastrointestinal (GI) symptoms. IBS is difficult to diagnose, as it is a functional GI disorder, determined after ruling out a myriad of other diagnoses. The 2016 Rome IV criteria define IBS as "a functional bowel disorder in which recurrent abdominal pain is associated with defecation or a change in bowel habits. Disordered bowel habits are typically present (ie, constipation, diarrhea, or a mix of constipation and diarrhea), as are symptoms of abdominal bloating/distension occurring over at least 6 months and not less than 3 months." Treatment of IBS historically has been through medical management; however, nutrition management of IBS using the FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols) elimination diet is now a recommended, first-line therapy. FODMAPs are short-chain, poorly absorbed carbohydrates that are associated with symptoms in people with IBS. This diet intervention can be quite challenging, and therefore, patients should meet with a qualified dietitian who can provide the complex diet information in a practicable form. Physician-dietitian collaboration is invaluable for IBS patients to achieve a successful outcome.
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A Renal Clinician's Guide to the Gut Microbiota.
Snelson, M, Biruete, A, McFarlane, C, Campbell, K
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 2020;(5):384-395
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Abstract
It is increasingly recognized that the gut microbiota plays a role in the progression of chronic diseases and that diet may confer health benefits by altering the gut microbiota composition. This is of particular relevance for chronic kidney disease (CKD), as the gut is a source of uremic retention solutes, which accumulate as a result of impaired kidney function and can exert nephrotoxic and other harmful effects. Kidney dysfunction is also associated with changes in the composition of the gut microbiota and the gastrointestinal tract. Diet modulates the gut microbiota, and there is much interest in the use of prebiotics, probiotics, and synbiotics as dietary therapies in CKD, as well as dietary patterns that beneficially alter the microbiota. This review provides an overview of the gut microbiota and its measurement, its relevance in the context of CKD, and the current state of knowledge regarding dietary manipulation of the microbiota.
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[Innovative approaches to study food patterns in functional gastrointestinal disorders].
Isakov, VA, Morozov, SV, Pilipenko, VI
Voprosy pitaniia. 2020;(4):172-185
Abstract
Dietary patterns play an important role in pathogenesis and treatment of functional gastrointestinal disorders. The aim - to perform literature review on modern approaches to perform nutritional assessment in functional gastrointestinal disorders and to summarize available data on its role in assessment of clinical manifestations and treatment of these conditions. Material and methods. A search was performed in the PubMed and Google scholar system with the use of keywords: "nutritional pattern", "dietary pattern", in combination with "methodology", "assessment", "functional gastrointestinal disorders", "GERD", "gastroesophageal reflux disease", "irritable bowel syndrome", "IBS", "small intestinal bacterial overgrowth", "treatment". The inclusion criteria were type of the paper (original study); they had to contain data on nutrition of patients with functional gastrointestinal disorders; main digital data should be present (sample size, design, diagnostic criteria, patients' eligibility criteria, control group characteristics, as well as results in quantitative characteristics and measure of dispersion of values). Results and discussion. Based on the data of 81 selected papers structured literature review was performed. We summarized the data on the methods of food patterns assessment, the knowledge on the food patterns in patients with functional gastrointestinal disorders (including gastroesophageal reflux disease and irritable bowel syndrome), clinical utility of the nutritional assessment with the use of food patterns. Assessment of nutritional patterns in patients with functional gastrointestinal disorders provides additional evidence that allows to correct the diet of these patients more effectively, to achieve better results of treatment in shorter time, to reduce the number of medications, and may be of use for the development of new functional foods.
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Can Probiotics and Diet Promote Beneficial Immune Modulation and Purine Control in Coronavirus Infection?
Morais, AHA, Passos, TS, Maciel, BLL, da Silva-Maia, JK
Nutrients. 2020;(6)
Abstract
Infection caused by the SARS-CoV-2 coronavirus worldwide has led the World Health Organization to declare a COVID-19 pandemic. Because there is no cure or treatment for this virus, it is emergingly urgent to find effective and validated methods to prevent and treat COVID-19 infection. In this context, alternatives related to nutritional therapy might help to control the infection. This narrative review proposes the importance and role of probiotics and diet as adjunct alternatives among the therapies available for the treatment of this new coronavirus. This review discusses the relationship between intestinal purine metabolism and the use of Lactobacillus gasseri and low-purine diets, particularly in individuals with hyperuricemia, as adjuvant nutritional therapies to improve the immune system and weaken viral replication, assisting in the treatment of COVID-19. These might be promising alternatives, in addition to many others that involve adequate intake of vitamins, minerals and bioactive compounds from food.