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1.
Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review.
Fiore, M, Oliveri Conti, G, Caltabiano, R, Buffone, A, Zuccarello, P, Cormaci, L, Cannizzaro, MA, Ferrante, M
International journal of environmental research and public health. 2019;(7)
Abstract
Environmental factors are recognized as risk factors of thyroid cancer in humans. Exposure to radiation, both from nuclear weapon or fallout or medical radiation, and to some organic and inorganic chemical toxicants represent a worldwide public health issue for their proven carcinogenicity. Halogenated compounds, such as organochlorines and pesticides, are able to disrupt thyroid function. Polychlorinated biphenyls and their metabolites and polybrominated diethyl ethers bind to thyroid, transport proteins, replace thyroxin, and disrupt thyroid function as phthalates and bisphenolates do, highly mimicking thyroid hormones. A better knowledge of environmental risks represents a very important tool for cancer prevention through true risks prevention and management. This approach is very important because of the epigenetic origin's theory of cancer. Therefore, the aim of this review was study the association between environmental agents and thyroid cancer promotion.
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2.
Steroids as Environmental Compounds Recalcitrant to Degradation: Genetic Mechanisms of Bacterial Biodegradation Pathways.
Olivera, ER, Luengo, JM
Genes. 2019;(7)
Abstract
Steroids are perhydro-1,2-cyclopentanophenanthrene derivatives that are almost exclusively synthesised by eukaryotic organisms. Since the start of the Anthropocene, the presence of these molecules, as well as related synthetic compounds (ethinylestradiol, dexamethasone, and others), has increased in different habitats due to farm and municipal effluents and discharge from the pharmaceutical industry. In addition, the highly hydrophobic nature of these molecules, as well as the absence of functional groups, makes them highly resistant to biodegradation. However, some environmental bacteria are able to modify or mineralise these compounds. Although steroid-metabolising bacteria have been isolated since the beginning of the 20th century, the genetics and catabolic pathways used have only been characterised in model organisms in the last few decades. Here, the metabolic alternatives used by different bacteria to metabolise steroids (e.g., cholesterol, bile acids, testosterone, and other steroid hormones), as well as the organisation and conservation of the genes involved, are reviewed.
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3.
Environmental safety and biosafety in construction biotechnology.
Ivanov, V, Stabnikov, V, Stabnikova, O, Kawasaki, S
World journal of microbiology & biotechnology. 2019;(2):26
Abstract
The topics of Construction Biotechnology are the development of construction biomaterials and construction biotechnologies for soil biocementation, biogrouting, biodesaturation, bioaggregation and biocoating. There are known different biochemical types of these biotechnologies. The most popular construction biotechnology is based on precipitation of calcium carbonate initiated by enzymatic hydrolysis of urea which follows with release of ammonia and ammonium to environment. This review focuses on the hazards and remedies for construction biotechnologies and on the novel environmentally friendly biotechnologies based on precipitation of hydroxyapatite, decay of calcium bicarbonate, and aerobic oxidation of calcium salts of organic acids. The use of enzymes or not living bacteria are the best options to ensure biosafety of construction biotechnologies. Only environmentally safe construction biotechnologies should be used for such environmental and geotechnical engineering works as control of the seepage in dams, channels, landfills or tunnels, sealing of the channels and the ponds, prevention of soil erosion and soil dust emission, mitigation of soil liquefaction, and immobilization of soil pollutants.
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4.
Exposure to environmental chemicals and type 1 diabetes: an update.
Howard, SG
Journal of epidemiology and community health. 2019;(6):483-488
Abstract
This narrative review summarises recently published epidemiological and in vivo experimental studies on exposure to environmental chemicals and their potential role in the development of type 1 diabetes mellitus (T1DM). These studies focus on a variety of environmental chemical exposures, including to air pollution, arsenic, some persistent organic pollutants, pesticides, bisphenol A and phthalates. Of the 15 epidemiological studies identified, 14 include measurements of exposures during childhood, 2 include prenatal exposures and 1 includes adults over age 21. Together, they illustrate that the role of chemicals in T1DM may be complex and may depend on a variety of factors, such as exposure level, timing of exposure, nutritional status and chemical metabolism. While the evidence that these exposures may increase the risk of T1DM is still preliminary, it is critical to investigate this possibility further as a means of preventing T1DM.
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5.
Mechanisms of Environmental Contributions to Fatty Liver Disease.
Wahlang, B, Jin, J, Beier, JI, Hardesty, JE, Daly, EF, Schnegelberger, RD, Falkner, KC, Prough, RA, Kirpich, IA, Cave, MC
Current environmental health reports. 2019;(3):80-94
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Abstract
PURPOSE Fatty liver disease (FLD) affects over 25% of the global population and may lead to liver-related mortality due to cirrhosis and liver cancer. FLD caused by occupational and environmental chemical exposures is termed "toxicant-associated steatohepatitis" (TASH). The current review addresses the scientific progress made in the mechanistic understanding of TASH since its initial description in 2010. RECENT FINDINGS Recently discovered modes of actions for volatile organic compounds and persistent organic pollutants include the following: (i) the endocrine-, metabolism-, and signaling-disrupting chemical hypotheses; (ii) chemical-nutrient interactions and the "two-hit" hypothesis. These key hypotheses were then reviewed in the context of the steatosis adverse outcome pathway (AOP) proposed by the US Environmental Protection Agency. The conceptual understanding of the contribution of environmental exposures to FLD has progressed significantly. However, because this is a new research area, more studies including mechanistic human data are required to address current knowledge gaps.
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6.
Alicycliphilus: current knowledge and potential for bioremediation of xenobiotics.
Solís-González, CJ, Loza-Tavera, H
Journal of applied microbiology. 2019;(6):1643-1656
Abstract
Alicycliphilus is a promising candidate for participating in the development of novel xenobiotics bioremediation processes. Members of the Alicycliphilus genus are environmental bacteria mostly found in polluted sites such as landfills and contaminated watercourses, and in sewage sludges from wastewater treatment plants. They exhibit a versatile metabolism and the ability to use oxygen, nitrate and chlorate as terminal electron acceptors, which allow them to biodegrade xenobiotics under oxic or anoxic conditions. Pure cultures of Alicycliphilus strains are able to biodegrade some pollutants such as industrial solvents (acetone, cyclohexanol and N-methylpyrrolidone), aromatic hydrocarbons (benzene, toluene and anthracene), as well as polyurethane varnishes and foams, and they can even transform Cr(VI) to Cr(III). In addition, Alicycliphilus has also been identified in bacterial communities involved in wastewater treatment plants for denitrification, and the degradation of emerging pollutants such as triclosan, nonylphenol, N-heterocyclic aromatic compounds (indole and quinoline), and antibiotics (tetracycline and oxytetracycline). This work summarizes the current knowledge on the Alicycliphilus genus, describing its different metabolic characteristics, focusing on its xenobiotic biodegradation abilities and examining the distinct pathways and molecular bases that sustain them. We also discuss the progress made in genetic manipulation and 'omics' analyses, as well as Alicycliphilus participation in novel bioremediation strategies.
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7.
Detection of potential biomarkers associated with outrageous diseases and environmental pollutants by nanoparticle-based immuno-PCR assays.
Dahiya, B, Mehta, PK
Analytical biochemistry. 2019;:113444
Abstract
Immuno-polymerase chain reaction (I-PCR) assay with advantages of both enzyme-linked immunosorbent assay (ELISA) and PCR exhibits several-fold enhanced sensitivity in comparison to respective ELISA, which has wide applications for ultralow detection of several molecules, i.e. cytokines, protooncogenes and biomarkers associated with several diseases. Conjugation of reporter DNA to the detection antibodies is the most crucial step of I-PCR assay that usually employs streptavidin-protein A, streptavidin-biotin conjugate or succinimidyl-4-(N-maleimidomethyl) cyclohexane-1-carboxylate (SMCC) system by a covalent binding. However, coupling of antibodies and oligonucleotides to nanoparticles (NPs) is relatively easier in the NP-based I-PCR (NP-I-PCR) that also displays better accuracy. This article is mainly focused on the detection of important biomarkers associated with several outrageous infectious and non-infectious diseases by NP-I-PCR assays, which would expedite an early initiation of therapy thus human health would be improved. Similarly, ultralow detection of environmental pollutants by these assays and their elimination would certainly improve human health.
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8.
Food components and environmental chemicals of inhibiting human placental aromatase.
Wang, Y, Pan, P, Li, X, Zhu, Q, Huang, T, Ge, RS
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2019;:46-53
Abstract
Human placental CYP19A1 catalyzes the estrogen synthesis from androgens. The enzyme is encoded by CYP19A1 gene located in chromosome 15q21. This enzyme is a monooxygenase in the smooth endoplasmic reticulum. The various promoters of the CYP19A1 gene determine its expression in different tissues and the distal promoter I.1 controls its expression in the placenta and retinoids can regulate the expression. Many food components and environmental chemicals inhibit CYP19A1 activity via different modes of action. These chemicals include gossypol, flavones, flavanones, chalconoids, resveratrol, and tobacco alkaloids derived from foods as well as phthalates, insecticides, fungicides, and biocides in the contaminated foods. The inhibition of placental CYP19A1 could impair pregnancy.
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9.
A review of the pathways of human exposure to poly- and perfluoroalkyl substances (PFASs) and present understanding of health effects.
Sunderland, EM, Hu, XC, Dassuncao, C, Tokranov, AK, Wagner, CC, Allen, JG
Journal of exposure science & environmental epidemiology. 2019;(2):131-147
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Abstract
Here, we review present understanding of sources and trends in human exposure to poly- and perfluoroalkyl substances (PFASs) and epidemiologic evidence for impacts on cancer, immune function, metabolic outcomes, and neurodevelopment. More than 4000 PFASs have been manufactured by humans and hundreds have been detected in environmental samples. Direct exposures due to use in products can be quickly phased out by shifts in chemical production but exposures driven by PFAS accumulation in the ocean and marine food chains and contamination of groundwater persist over long timescales. Serum concentrations of legacy PFASs in humans are declining globally but total exposures to newer PFASs and precursor compounds have not been well characterized. Human exposures to legacy PFASs from seafood and drinking water are stable or increasing in many regions, suggesting observed declines reflect phase-outs in legacy PFAS use in consumer products. Many regions globally are continuing to discover PFAS contaminated sites from aqueous film forming foam (AFFF) use, particularly next to airports and military bases. Exposures from food packaging and indoor environments are uncertain due to a rapidly changing chemical landscape where legacy PFASs have been replaced by diverse precursors and custom molecules that are difficult to detect. Multiple studies find significant associations between PFAS exposure and adverse immune outcomes in children. Dyslipidemia is the strongest metabolic outcome associated with PFAS exposure. Evidence for cancer is limited to manufacturing locations with extremely high exposures and insufficient data are available to characterize impacts of PFAS exposures on neurodevelopment. Preliminary evidence suggests significant health effects associated with exposures to emerging PFASs. Lessons learned from legacy PFASs indicate that limited data should not be used as a justification to delay risk mitigation actions for replacement PFASs.
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10.
The History of the Dioxin issue in Brazil: From citrus pulp crisis to food monitoring (REVIEW).
de Lacerda, JPA
Environment international. 2019;:11-20
Abstract
Dioxins and furans are ubiquitous, anthropogenic environmental contaminants which can be found even in isolated places. Exposition to these chemicals poses several risks to humans such as thyroid dysfunction, cardiovascular diseases, and even cancer. In this review, the dioxin issue is analyzed in the light of the events that brought the World's attention to these pollutants, and the evolution of Brazilian scientific data on this matter since the citrus pulp crisis in 1998. Soil and air have been the main environmental matrices studied in Brazil. However, most of the research focuses on contaminated areas, with few or no data available on background levels. With the ratification of the Stockholm Convention in 2010, Brazil started to implement some measures to monitor the release of dioxins to the environment, such as the national inventory of sources. Still, the country lacks specific legislation stating acceptable limits for some industrial processes known to be source of dioxins emissions. Likewise, food monitoring has grown in recent years with the expansion of food groups monitored in the National Control Plan for Residues and Contaminants, but the available data do not allow affirming whether Brazilian residents are safe, as regard to exposure via food consumption. The implementation of a systemic survey such as a Total Diet Study would be a good strategy for a long-term monitoring not only for dioxins but also for other contaminants. Unfortunately, progressive cuts in science funds are holding back the scientific production in Brazil, whereas worldwide new emerging contaminants are being monitored and included in National Monitoring Plans both on food and environment matrices.