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Nitric oxide in occurrence, progress and therapy of lung Cancer: a systemic review and meta-analysis.
Zhou, H, Li, J, Chen, Z, Chen, Y, Ye, S
BMC cancer. 2021;(1):678
Abstract
BACKGROUND Nitric oxide (NO) plays an important role in lung cancer. However, the results of previous studies about NO in the occurrence, progress and therapy were not consistent. Therefore, we conducted a meta-analysis to evaluate the relationship between NO and lung cancer. METHOD We carried out comprehensive search in the databases, and collected related studies. The data of fraction of exhaled nitric oxide (FeNO) or blood NO in different populations (lung cancer patients and control subjects) and different time points (before therapy and after therapy) were extracted by two investigators. A random effect model was applied to analyze the differences of FeNO and blood NO in different populations and different time points. To further compare NO level of each subgroup with different pathological types and different stages, a network meta-analysis (NMA) was performed. RESULTS Fifty studies including 2551 cases and 1691 controls were adopted in this meta-analysis. The FeNO (SMD 3.01, 95% CI 1.89-4.13, p < 0.00001) and blood NO (SMD 1.34, 95% CI 0.84-1.85, p < 0.00001) level in lung cancer patients was much higher than that in control subjects. NMA model indicated blood NO level in each cancer type except SCLC was higher than that in control patients. There was no significant difference of blood NO level among four kinds of lung cancer patients. Blood NO level in LCC patients (SUCRA = 83.5%) was the highest. Blood NO level in advanced stage but not early stage was higher than that in control subjects. Patients in advanced stage (SUCRA = 95.5%) had the highest blood NO level. No significant difference of FeNO (SMD -0.04, 95% CI -0.46-0.38, p > 0.05) and blood NO level (SMD -0.36, 95% CI -1.08-0.36, p > 0.05) was observed between pretreatment and posttreatment in all patients. However, FeNO level elevated (SMD 0.28, 95% CI 0.04-0.51, p = 0.02) and blood NO level decreased in NSCLC patients (SMD -0.95, 95% CI -1.89-0.00, p = 0.05) after therapy. CONCLUSION FeNO and blood NO level would contribute to diagnosis of lung cancer and evaluation of therapy effect, especially for NSCLC patients.
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Nitric oxide (NO) levels in patients with polycystic ovary syndrome (PCOS): a meta-analysis.
Meng, C
The Journal of international medical research. 2019;(9):4083-4094
Abstract
OBJECTIVE The pathogenesis of polycystic ovarian syndrome (PCOS) remains unclear, but is known to be related to increased insulin resistance, diabetes, obesity, oxidative stress, inflammation, and cardiovascular disease. No meta-analyses have examined whether PCOS is associated with nitric oxide (NO). Therefore, we aimed to evaluate the association between serum/plasma nitrite levels and PCOS. METHODS We performed a meta-analysis. To identify eligible original articles, we searched online computerized databases, including EMBASE, Medline, and Web of Science. The characteristics of each single study, as well as the standard mean difference (SMD) with corresponding confidence intervals (CIs), were calculated and subgroup analysis was performed to examine heterogeneity. RESULTS We included 12 articles with 16 studies and a total of 895 patients were included in the meta-analysis. We found a significant association between PCOS and serum or plasma nitrite levels, with a pooled SMD of −0.61 (95% CI: −1.05 to −0.16). The final pooled data were determined by the random effects model because significant high heterogeneity (I2 = 89%) was found. CONCLUSIONS Our meta-analysis shows that decreased serum or plasma nitrite levels are associated with PCOS. The pathogenesis of PCOS may be due to endothelial dysfunction; however, further research to confirm this possibility is required.
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Associations of the NOS3 rs1799983 polymorphism with circulating nitric oxide and lipid levels: a systematic review and meta-analysis.
Luo, Z, Jia, A, Lu, Z, Muhammad, I, Adenrele, A, Song, Y
Postgraduate medical journal. 2019;(1125):361-371
Abstract
BACKGROUND Circulating nitric oxide (NO) and lipid levels are closely associated with coronary artery disease (CAD). It is unclear whether the rs1799983 polymorphism in endothelial nitric oxide synthase (NOS3) gene is associated with plasma levels of NO and lipids. This systematic review and meta-analysis (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) aimed to clarify the relationships between the rs1799983 polymorphism and plasma levels of NO and lipids. METHODS Sixteen studies (2702 subjects) and 59 studies (14 148 subjects) were identified for the association analyses for NO and lipids, respectively. Mean difference (MD) and 95% CI were used to estimate the effects of the rs1799983 polymorphism on plasma NO and lipid levels. The primary outcome variable was NO, and the secondary outcomes included triglycerides, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C). RESULTS Carriers of the T allele had lower levels of NO (MD -0.27 μmol/L, 95% CI -0.42 to -0.12 μmol/L, p<0.001) and HDL-C (MD -0.07 mmol/L, 95% CI -0.14 to -0.00 mmol/L, p=0.04), and higher levels of TC (MD 0.13 mmol/L, 95% CI 0.06 to 0.20 mmol/L, p<0.001) and LDL-C (MD 0.14 mmol/L, 95% CI 0.05 to 0.22 mmol/L, p=0.002) than the non-carriers. Triglyceride levels were comparable between the genotypes. CONCLUSION The association between the NOS3 rs1799983 polymorphism and CAD may be partly mediated by abnormal NO and lipid levels caused by the T allele.
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A meta-analysis of biomarkers related to oxidative stress and nitric oxide pathway in migraine.
Neri, M, Frustaci, A, Milic, M, Valdiglesias, V, Fini, M, Bonassi, S, Barbanti, P
Cephalalgia : an international journal of headache. 2015;(10):931-7
Abstract
BACKGROUND Oxidative and nitrosative stress are considered key events in the still unclear pathophysiology of migraine. METHODS Studies comparing the level of biomarkers related to nitric oxide (NO) pathway/oxidative stress in the blood/urine of migraineurs vs. unaffected controls were extracted from the PubMed database. Summary estimates of mean ratios (MR) were carried out whenever a minimum of three papers were available. Nineteen studies were included in the meta-analyses, accounting for more than 1000 patients and controls, and compared with existing literature. RESULTS Most studies measuring superoxide dismutase (SOD) showed lower activity in cases, although the meta-analysis in erythrocytes gave null results. On the contrary, plasma levels of thiobarbituric acid reactive substances (TBARS), an aspecific biomarker of oxidative damage, showed a meta-MR of 2.20 (95% CI: 1.65-2.93). As for NOs, no significant results were found in plasma, serum and urine. However, higher levels were shown during attacks, in patients with aura, and an effect of diet was found. The analysis of glutathione precursor homocysteine and asymmetric dimethylarginine (ADMA), an NO synthase inhibitor, gave inconclusive results. CONCLUSIONS The role of the oxidative pathway in migraine is still uncertain. Interesting evidence emerged for TBARS and SOD, and concerning the possible role of diet in the control of NOx levels.