-
1.
Current Status and Future Perspective for Research on Medicinal Plants with Anticancerous Activity and Minimum Cytotoxic Value.
Qamar, H, Rehman, S, Chauhan, DK
Current drug targets. 2019;(12):1227-1243
Abstract
Cancer is the second leading cause of morbidity and mortality worldwide. Although chemotherapy and radiotherapy enhance the survival rate of cancerous patients but they have several acute toxic effects. Therefore, there is a need to search for new anticancer agents having better efficacy and lesser side effects. In this regard, herbal treatment is found to be a safe method for treating and preventing cancer. Here, an attempt has been made to screen some less explored medicinal plants like Ammania baccifera, Asclepias curassavica, Azadarichta indica, Butea monosperma, Croton tiglium, Hedera nepalensis, Jatropha curcas, Momordica charantia, Moringa oleifera, Psidium guajava, etc. having potent anticancer activity with minimum cytotoxic value (IC50 >3μM) and lesser or negligible toxicity. They are rich in active phytochemicals with a wide range of drug targets. In this study, these medicinal plants were evaluated for dose-dependent cytotoxicological studies via in vitro MTT assay and in vivo tumor models along with some more plants which are reported to have IC50 value in the range of 0.019-0.528 mg/ml. The findings indicate that these plants inhibit tumor growth by their antiproliferative, pro-apoptotic, anti-metastatic and anti-angiogenic molecular targets. They are widely used because of their easy availability, affordable price and having no or sometimes minimal side effects. This review provides a baseline for the discovery of anticancer drugs from medicinal plants having minimum cytotoxic value with minimal side effects and establishment of their analogues for the welfare of mankind.
-
2.
[Research progress of studies on chemical constituents and biologic activities of Anemone species].
Liu, Y, Liu, L, Tian, CK, Zhou, DZ
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. 2019;(5):912-919
Abstract
Anemone is an important genus which was distributed widely and used to folk medicines in China. It is rich of pentacyclic triterpenoid saponins,and more than 100 kinds of pentacyclic triterpenoid saponins had been isolated and identified. Anemone has been used to treat punch injury and rheumatoid arthritis. This article reviews the latest research progress of Anemone decoction from two aspects: chemical constituents and pharmacological. It will provide reference for further research and development of Anemone.
-
3.
Medicinal Plants As Natural Polarizers of Macrophages: Phytochemicals and Pharmacological Effects.
Davoodvandi, A, Sahebnasagh, R, Mardanshah, O, Asemi, Z, Nejati, M, Shahrzad, MK, Mirzaei, HR, Mirzaei, H
Current pharmaceutical design. 2019;(30):3225-3238
Abstract
Macrophages are one of the crucial mediators of the immune response in different physiological and pathological conditions. These cells have critical functions in the inflammation mechanisms that are involved in the inhibition or progression of a wide range of diseases including cancer, autoimmune diseases, etc. It has been shown that macrophages are generally divided into two subtypes, M1 and M2, which are distinguished on the basis of their different gene expression patterns and phenotype. M1 macrophages are known as pro-inflammatory cells and are involved in inflammatory mechanisms, whereas M2 macrophages are known as anti-inflammatory cells that are involved in the inhibition of the inflammatory pathways. M2 macrophages help in tissue healing via producing anti-inflammatory cytokines. Increasing evidence indicated that the appearance of different macrophage subtypes is associated with the fate of diseases (progression versus suppression). Hence, polarization of macrophages can be introduced as an important venue in finding, designing and developing novel therapeutic approaches. Albeit, there are different pharmacological agents that are used for the treatment of various disorders, it has been shown that several natural compounds have the potential to regulate M1 to M2 macrophage polarization and vice versa. Herein, for the first time, we summarized new insights into the pharmacological effects of natural compounds on macrophage polarization.
-
4.
Medicinal plants brought by Indian indentured immigrants: A comparative review of ethnopharmacological uses between Mauritius and India.
Mahomoodally, MF, Protab, K, Aumeeruddy, MZ
Journal of ethnopharmacology. 2019;:245-289
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE Mauritius is famous for its floricultural diversity and traditions practiced across the island by various ethnic groups. During the British rule in the 1835s, Indian indentured labourers migrated to Mauritius and played a very important role in shaping the Mauritian culture. They brought along their high heritage of traditional knowledge of certain medicinal herbs and spices. Nonetheless, there has been no comparative study to investigate whether these past traditional knowledge are still preserved in Mauritius and India. AIM OF THE STUDY To document and compare the traditional uses of medicinal herbs and spices brought by Indian indentured labourers with their current uses in Mauritius and India, and to review pharmacological studies of such plants. MATERIALS AND METHODS Locally published textbooks, research dissertations, and relevant records from the 'Mauritiana' section of the University of Mauritius library were scrutinised for possible early records of such herbs and spices brought by Indian indentured immigrants. Field trips and site visits to Mauritius Herbarium and The National Folk Museum were conducted to gather data on their traditional uses as practiced by the Indian indentured immigrants. A literature search was performed to gather the current ethnomedicinal uses of these plants in Mauritius and India using key databases such as ScienceDirect and PubMed, as well as thesis from local university website. Pharmacological studies on these plants were also reviewed in an attempt to compare the ethnomedicinal uses against reported ailments. RESULTS Indian labourers brought 18 medicinal plants for medicinal purposes as documented at the folk museum of Indian Immigration. Piper betle L., Azadirachta indica A. Juss., and Curcuma longa L. were common plants used by Indian indentured immigrants against a wide range of ailments. Data obtained from recent ethnomedicinal surveys revealed that A. indica and C. longa were the most traditionally used plants in India, while in Mauritius, C. longa was the most popular plant followed by Allium sativum L. and Ocimum tenuiflorum L. It was also found that all these plants are currently being used against a wide range of diseases in both countries. In addition, several studies have highlighted the pharmacological properties such as analgesic, anti-inflammatory, anti-microbial, anti-pyretic, and anti-diabetic for some plants. CONCLUSION This investigation can be considered as a first attempt to document and compare traditional knowledge of medicinal plants brought by Indian immigrants. We observed that some of these knowledge are preserved and still practiced in Mauritius. It is anticipated that this study will revive the interest in safeguarding and promoting the ancestral knowledge on the uses of such plants.
-
5.
Phytochemistry and pharmacological activities of the genus Rhynchosia: a comprehensive review.
Rammohan, A, Reddy, GM, Bhaskar, BV, Gunasekar, D, Zyryanov, GV
Planta. 2019;(1):9
Abstract
The genus Rhynchosia is a rich source of natural compounds especially flavonoids and prenylated isoflavonoids. Further experimental studies on Rhynchosia members may be result new and novel secondary metabolites with potent biological activities. Traditionally, medicinal plants have played a significant role on human life since ancient days. At present, natural compounds are the major source for the modern drug discovery owing to their therapeutic selectivity, minutest of side effects, inexpensive source and serve as lead molecules for the discovery of new drugs. Rhynchosia species (Fabaceae) are extensively circulated throughout the tropical and subtropical areas around the world. A few plants of this genus were used in traditional medicine for the treatment of various ailments such as antibacterial, antidiabetic, abortifacients, healing of wounds, hepatoprotective, remedial of boils, rheumatic pains and skin infections. The present review compiles traditional uses, isolated chemical compounds and pharmacological activities of Rhynchosia species. So far, in total, seventy-seven compounds were isolated from the genus Rhynchosia, including flavonoids, isoflavonoids, flavan-3-ols, xanthones, biphenyls, simple polyphenols and sterols. It is interesting to note that the genus Rhynchosia is a rich source of C-glycosylflavonoids and prenylated isoflavonoids. Further, phytochemical and pharmacological studies on this genus are required since only few species have been investigated so far.
-
6.
Evaluation of the Anti-Diabetic Activity of Some Common Herbs and Spices: Providing New Insights with Inverse Virtual Screening.
Pereira, ASP, Banegas-Luna, AJ, Peña-García, J, Pérez-Sánchez, H, Apostolides, Z
Molecules (Basel, Switzerland). 2019;(22)
Abstract
Culinary herbs and spices are widely used as a traditional medicine in the treatment of diabetes and its complications, and there are several scientific studies in the literature supporting the use of these medicinal plants. However, there is often a lack of knowledge on the bioactive compounds of these herbs and spices and their mechanisms of action. The aim of this study was to use inverse virtual screening to provide insights into the bioactive compounds of common herbs and spices, and their potential molecular mechanisms of action in the treatment of diabetes. In this study, a library of over 2300 compounds derived from 30 common herbs and spices were screened in silico with the DIA-DB web server against 18 known diabetes drug targets. Over 900 compounds from the herbs and spices library were observed to have potential anti-diabetic activity and liquorice, hops, fennel, rosemary, and fenugreek were observed to be particularly enriched with potential anti-diabetic compounds. A large percentage of the compounds were observed to be potential polypharmacological agents regulating three or more anti-diabetic drug targets and included compounds such as achillin B from yarrow, asparasaponin I from fenugreek, bisdemethoxycurcumin from turmeric, carlinoside from lemongrass, cinnamtannin B1 from cinnamon, crocin from saffron and glabridin from liquorice. The major targets identified for the herbs and spices compounds were dipeptidyl peptidase-4 (DPP4), intestinal maltase-glucoamylase (MGAM), liver receptor homolog-1 (NR5A2), pancreatic alpha-amylase (AM2A), peroxisome proliferator-activated receptor alpha (PPARA), protein tyrosine phosphatase non-receptor type 9 (PTPN9), and retinol binding protein-4 (RBP4) with over 250 compounds observed to be potential inhibitors of these particular protein targets. Only bay leaves, liquorice and thyme were found to contain compounds that could potentially regulate all 18 protein targets followed by black pepper, cumin, dill, hops and marjoram with 17 protein targets. In most cases more than one compound within a given plant could potentially regulate a particular protein target. It was observed that through this multi-compound-multi target regulation of these specific protein targets that the major anti-diabetic effects of reduced hyperglycemia and hyperlipidemia of the herbs and spices could be explained. The results of this study, taken together with the known scientific literature, indicated that the anti-diabetic potential of common culinary herbs and spices was the result of the collective action of more than one bioactive compound regulating and restoring several dysregulated and interconnected diabetic biological processes.
-
7.
Melatonin in Medicinal and Food Plants: Occurrence, Bioavailability, and Health Potential for Humans.
Salehi, B, Sharopov, F, Fokou, PVT, Kobylinska, A, Jonge, L, Tadio, K, Sharifi-Rad, J, Posmyk, MM, Martorell, M, Martins, N, et al
Cells. 2019;(7)
Abstract
Melatonin is a widespread molecule among living organisms involved in multiple biological, hormonal, and physiological processes at cellular, tissue, and organic levels. It is well-known for its ability to cross the blood-brain barrier, and renowned antioxidant effects, acting as a free radical scavenger, up-regulating antioxidant enzymes, reducing mitochondrial electron leakage, and interfering with proinflammatory signaling pathways. Detected in various medicinal and food plants, its concentration is widely variable. Plant generative organs (e.g., flowers, fruits), and especially seeds, have been proposed as having the highest melatonin concentrations, markedly higher than those found in vertebrate tissues. In addition, seeds are also rich in other substances (lipids, sugars, and proteins), constituting the energetic reserve for a potentially growing seedling and beneficial for the human diet. Thus, given that dietary melatonin is absorbed in the gastrointestinal tract and transported into the bloodstream, the ingestion of medicinal and plant foods by mammals as a source of melatonin may be conceived as a key step in serum melatonin modulation and, consequently, health promotion.
-
8.
25 years after the `Rio Convention'--Lessons learned in the context of sustainable development and protecting indigenous and local knowledge.
Heinrich, M, Hesketh, A
Phytomedicine : international journal of phytotherapy and phytopharmacology. 2019;:332-343
Abstract
BACKGROUND When in 1992 the Convention on Biological Diversity was adopted, it was a response to centuries of exploitative use of biodiversity and to a lack of recognition of the rights of the countries and regions of origin. At the same time, it was an outcome of the increasing drive, especially in many European and American countries, to ascertain more equitable sharing of wealth between the global North and South. It is a result of negotiations between states and driven by political consensus. AIM: With this review we aim to assess the situation 25 years after the adoption of the CBD, provide an overview on how we got to the current framework and offer a perspective on how such access rights and equitable benefit sharing can be ascertained. OUTCOMES AND DISCUSSION Without doubt the CBD has resulted in a new framework for providing and securing access to biodiversity and for equitable benefit sharing. It has since been developed and amended in numerous treaties and protocols, most recently the Nagoya Protocol. This development is both driven by the historical experience of many countries in the exploitative extractions of biodiversity, and indigenous peoples' drive for the recognition of their rights. Examples of exploitative use of biodiversity include the species yielding quinine and rubber. Using Lepidium meyenii Walp. as an example, we assess the current patent basis and highlight why in this case equitable benefit sharing proved to be impossible. Today, there are well-established principles in place to establish intellectual property rights, both with respect to a country's ownership of genetic resources, and a research entity's invention based on them. There remains, however, a lack of investment as well as research and development opportunities based on these internationally binding agreements. In line with the aims of our review, this paper includes an overview on how the current patenting system can be used to ensure that the goals of the CBD can be achieved. CONCLUSION In the context of the centuries of exploitative use of biodiversity, 25 years is a short time span and this review reiterates Posey and Dutfields' call (1996) to companies or other outside organization for developing 'a relationship in which the community is an equal partner'.
-
9.
Medicinal Uses, Phytochemistry and Pharmacological Properties of Elaeodendron transvaalense.
Maroyi, A, Semenya, SS
Nutrients. 2019;(3)
Abstract
Elaeodendron transvaalense is a plant species, which is in high demand as a herbal medicine in southern Africa. This study critically reviewed the medicinal applications, phytochemistry and pharmacological activities of E. transvaalense. The literature on medicinal applications, phytochemical, and pharmacological activities of E. transvaalense, was collected from multiple internet sources including Elsevier, Google Scholar, SciFinder, Web of Science, Pubmed, BMC, Science Direct, and Scopus. Complementary information was gathered from pre-electronic sources, such as books, book chapters, theses, scientific reports, and journal articles obtained from the University library. This study revealed that the species is used as herbal medicine in 62.5% of the countries where E. transvaalense is native in southern Africa. It is mainly used as herbal medicine for diarrhoea, menorrhagia, stomach aches, skin infections, inflammations, and rashes. Phytochemical compounds identified from the species, include flavonoids, peltogynoid, phenols, proanthocyanidins, tannin, and triterpenes. Ethnopharmacological research revealed that extracts and phytochemical constituents isolated from E. transvaalense have antibacterial, antifungal, anti-HIV, anti-inflammatory, antioxidant, antiplasmodial, anti-protozoan, anti-pyretic, hypoglycaemic, larvicidal, cytotoxicity, and mutagenic activities. Elaeodendron transvalense should to be subjected to detailed phytochemical, pharmacological, and toxicological evaluations aimed at correlating the medicinal uses of the species with the ethnopharmacological properties of the species.
-
10.
Phytomedicines in the Treatment of Migraine.
Rajapakse, T, Davenport, WJ
CNS drugs. 2019;(5):399-415
Abstract
Migraine is a disabling neurovascular disorder with few targeted, tolerable and effective treatments. Phytomedicines, or plant-based medicinal formulations, hold great promise in the identification of novel therapeutic targets in migraine. Many patients also turn toward herbal and plant-based therapies for the treatment of their migraines as clinical and preclinical evidence of efficacy increases. Patients seek effective and tolerable treatments instead of or in addition to current conventional pharmacologic therapies. We review some phytomedicines potentially useful for migraine treatment-feverfew (Tanacetum parthenium), butterbur (Petasites hybridus), marijuana (Cannabis spp.), Saint John's Wort (Hypericum perforatum) and the Damask rose (Rosa × damascena)-with respect to their mechanisms of action and evidence for treatment of migraine. The evidence for feverfew is mixed; butterbur is effective with potential risks of hepatotoxicity related to preparation; marijuana has not been shown to be effective in migraine treatment, and data are scant; Saint John's Wort shows relevant physiological activity but is a hepatic enzyme inducer and lacks clinical studies for this purpose; the Damask rose when used in topical preparations did not show efficacy in one clinical trial. Other plant preparations have been considered for migraine treatment but most without blinded randomized, placebo-controlled trial evidence.