1.
Posterior reversible encephalopathy syndrome in a patient with chronic obstructive pulmonary disease.
Dietvorst, S, Lambert, J, Demeestere, J, Lemmens, R
Acta neurologica Belgica. 2020;(1):163-165
2.
Increased IL-17RA and IL-17RC in End-Stage COPD and the Contribution to Mast Cell Secretion of FGF-2 and VEGF.
Roos, AB, Mori, M, Gura, HK, Lorentz, A, Bjermer, L, Hoffmann, HJ, Erjefält, JS, Stampfli, MR
Respiratory research. 2017;(1):48
Abstract
Mast cells are accumulated in advanced chronic obstructive pulmonary disease (COPD), and interleukin (IL)-17 signaling plays a role in disease progression. The expression, localization and functional relevance of IL-17 receptor (R)A and IL-17RC was explored in COPD by immunodetection, and functional assays.IL-17RA and IL-17RC was increased in very severe COPD, and expressed by mast cells. Increased secretion of the pro-angiogenic basic fibroblast growth factor and vascular endothelial growth factor was observed in vitro-maintained mast cells stimulated with IL-17A. Expression of these mediators was confirmed in end-stage COPD. Thus, accumulation of mast cells in COPD may contribute to vascular remodeling.