1.
Acute myocardial infarction associated with thinner abuse: case report and literature review.
Velibey, Y, Altay, S, Terzi, S, Yesilcimen, K, Golcuk, Y, Gunay, E
Clinical toxicology (Philadelphia, Pa.). 2013;(7):725-6
2.
Occupational trichloroethylene hypersensitivity syndrome with human herpesvirus-6 and cytomegalovirus reactivation.
Watanabe, H, Tohyama, M, Kamijima, M, Nakajima, T, Yoshida, T, Hashimoto, K, Iijima, M
Dermatology (Basel, Switzerland). 2010;(1):17-22
Abstract
Patients having a generalised rash with severe liver dysfunction associated with exposure to trichloroethylene (TCE) have been reported mainly in Asian countries. However, no case has been reported in Japan since the 1990s. Here, we describe a case of hypersensitivity syndrome (HS) caused by TCE in a 30-year-old Japanese man. The patient developed a rash, fever and liver dysfunction 21 days after he had been exposed to TCE at his workplace. Serum human herpesvirus (HHV)-6 and cytomegalovirus (CMV) DNA were detected 4 and 7 weeks, respectively, after the onset; the IgG antibody titres to HHV-6 and CMV were significantly elevated 6 and 9 weeks, respectively, after the onset. Patch testing was positive for the metabolites of TCE (i.e. trichloroethanol, trichloroacetic acid and chloral hydrate) but not for TCE itself; these results suggest that the TCE metabolites induced this disease. Human leucocyte antigen-B*1301, which has been reported to be strongly associated with TCE-induced HS, was identified in this patient. In addition, the clinical findings, laboratory data and period of virus reactivation after onset were quite similar to those of drug-induced hypersensitivity syndrome (DIHS). We also review TCE-induced HS from the viewpoint of the similarity to DIHS in this article.
3.
Fomepizole as a therapeutic strategy in paediatric methanol poisoning. A case report and review of the literature.
De Brabander, N, Wojciechowski, M, De Decker, K, De Weerdt, A, Jorens, PG
European journal of pediatrics. 2005;(3):158-61
Abstract
UNLABELLED Methanol poisoning is not frequently observed in children; however, without treatment, serious intoxication can be complicated by visual impairment, coma, metabolic acidosis, respiratory and circulatory insufficiency and death. Treatment in a paediatric intensive care is therefore compulsory. Methanol is metabolised in the liver by alcohol dehydrogenase to the toxic metabolites formaldehyde and formic acid. Classically, ethanol is given as a competitive inhibitor in order to avoid the formation of these compounds. We report on the use of fomepizole (4-methylpyrazole),a new and potent inhibitor of alcohol dehydrogenase, in a 3-year-old boy after the intake of a toxic amount of methanol. The course was uneventful and the use of fomepizole was not accompanied by any side-effects. An overview is given of all cases of paediatric poisoning in which fomepizole was used. CONCLUSION Fomepizole seems to be a safe and valid alternative to ethanol in cases of paediatric methanol poisoning.