-
1.
The influence of oxytocin on eating behaviours and stress in women with bulimia nervosa and binge eating disorder.
Leslie, M, Leppanen, J, Paloyelis, Y, Treasure, J
Molecular and cellular endocrinology. 2019;:110354
Abstract
The current study aimed to test the influence of oxytocin on palatable food intake, 24-h caloric consumption, and stress in women with bulimia nervosa and binge eating disorder. We recruited 25 women with DSM-5 bulimia nervosa or binge eating disorder, and 27 weight-matched comparison women without history of an eating disorder. We employed a double-blind, placebo-controlled crossover design in which each participant attended the lab for two experimental sessions, receiving a divided dose of 64IU intranasal oxytocin in one session and equivalent volume of placebo nasal spray in the opposite session. The order of administration was pseudo-randomised across participants. We hypothesised that a divided dose of 64IU intranasal oxytocin administration would reduce subjective hunger, the immediate consumption of palatable food, 24-h calorie consumption, and the incidence of binge eating when compared to placebo. We also hypothesised that oxytocin administration would be associated with lower levels of stress and salivary cortisol, and that there would be an interaction with participant group such that oxytocin would reduce eating behaviour and stress to a greater degree in women with bulimia nervosa or binge eating disorder, compared to women without history of an eating disorder. We did not find a significant effect of oxytocin on any of the measurements of eating behaviour, subjective stress, or salivary cortisol. We recommend that future studies test the dose-response effect of oxytocin on eating behaviours and stress in human populations with eating disorders to further clarify the moderating factors for oxytocin's effect on eating.
-
2.
Stress management in obesity during a thermal spa residential programme (ObesiStress): protocol for a randomised controlled trial study.
Dutheil, F, Chaplais, E, Vilmant, A, Courteix, D, Duche, P, Abergel, A, Pfabigan, DM, Han, S, Mobdillon, L, Vallet, GT, et al
BMJ open. 2019;(12):e027058
Abstract
INTRODUCTION Stress and obesity are two public health issues. The relationship between obesity and stress is biological through the actions of stress on the major hormones that regulate appetite (leptin and ghrelin). Many spa resorts in France specialise in the treatment of obesity, but no thermal spa currently proposes a specific programme to manage stress in obesity. The ObesiStress protocol has been designed to offer a new residential stress management programme. This thermal spa treatment of obesity implements stress management strategies as suggested by international recommendations. METHODS AND ANALYSIS 140 overweight or obese participants with a Body Mass Index of >25 kg/m2 and aged over 18 years will be recruited. Participants will be randomised into two groups: a control group of usual practice (restrictive diet, physical activity and thermal spa treatment) and an intervention group with stress management in addition to the usual practice. In the present protocol, parameters will be measured on five occasions (at inclusion, at the beginning of the spa (day 0), at the end of the spa (day 21), and at 6 and 12 months). The study will assess the participants' heart rate variability, cardiac remodelling and function, electrodermal activity, blood markers, anthropometric profile, body composition, psychology and quality of life via the use of questionnaires and bone parameters. ETHICS AND DISSEMINATION The ObesiStress protocol complies with the ethics guidelines for Clinical Research and has been approved by the ethics committee (CPP Sud-Est VI, Clermont-Ferrand - ANSM 2016-A01774-47). This study aimed to highlight the efficacy of a 21-day thermal spa residential programme of stress management in obesity through objective measurements of well-being and cardiovascular morbidity. Results will be disseminated during several research conferences and articles published in peer-reviewed journals. TRIAL REGISTRATION NUMBER NCT03578757.
-
3.
Eat to avoid negative self-awareness: Locus of control and core self-evaluation as serial mediators in the effect of stress on food intake.
Qi, W, Cui, L
Appetite. 2019;:104401
Abstract
The primary hypothesis of escape theory lies in that those who are under stress eat to escape from negative self-awareness. Although escape theory has been well cited in the eating literature, relatively few studies have directly tested its applicability to stress-induced eating. The aim of the present study is to provide causal evidence on using escape theory to explain the effect of stress on food intake. Specifically, we examined whether locus of control (LOC) and core self-evaluation (CSE) are serial mediators in the effect of stress on food intake. By a longitudinal experimental design, participants were randomly assigned to a stress group or a control group, and data on LOC, CSE, and food intake were collected at 3 waves. The results indicated that LOC and CSE are serial mediators in the effect of stress on food intake, though the direct effect of stress conditions remained significant. Our findings support the applicability of escape theory to interpret why stress increases food intake, and exclusion of LOC as an indicator of CSE. Thus, the present study provides causal evidence on escape theory by shedding light on the sequential mediating effect of LOC and CSE. Future research need to pay more attention to the evaluative process in stress-induced eating.
-
4.
Childhood adversity and women's cardiometabolic health in adulthood: associations with health behaviors, psychological distress, mood symptoms, and personality.
van Dammen, L, Bush, NR, de Rooij, SR, Mol, BWJ, Groen, H, Hoek, A, Roseboom, TJ
BMC women's health. 2019;(1):102
Abstract
BACKGROUND We tested whether childhood adversity is associated with poor cardiometabolic health in adulthood among a sample of overweight or obese Dutch women of reproductive age. Health behaviors, psychological distress, mood symptoms, or personality traits were included as potential mediators. METHODS Data came from a follow-up visit (N = 115), carried out in 2016/2017, of a randomized controlled lifestyle intervention trial in 577 obese infertile women. The associations between total adversity exposure score and cardiometabolic health were tested with regression models. Sleep, smoking and eating behavior, symptoms of depression, anxiety and stress, and personality traits were potential mediators. RESULTS Childhood adversity scores were not associated with cardiometabolic outcomes but were associated with poorer sleep quality score (M = 7.2 (SD = 3.5) for those with ≥2 types of events versus 4.8 (2.9) for those with no events; p = 0.022), higher external eating score (26.4 (8.7) versus 21.8 (10.3); p = 0.038), higher perceived stress score (17.1 (6.8) versus 12.3 (4.5); p = 0.016), post-traumatic stress score (1.9 (1.5) versus 0.6 (1.1); p < 0.001), and lower agreeableness score (28.2 (4.2) versus 30.3 (3.1); p = 0.035). CONCLUSION Childhood adversity was associated with poorer health behaviors including sleep and eating behavior, and more stress-related symptoms, but not with women's cardiometabolic health.
-
5.
Female Volleyball Players Are More Prone to Cortisol Anticipatory Stress Response than Sedentary Women.
Dziembowska, I, Wójcik, M, Hołyńska-Iwan, I, Litwic-Kaminska, K, Słomka, A, Żekanowska, E
Medicina (Kaunas, Lithuania). 2019;(6)
Abstract
Background and Objectives: Top-level sports performance places heavy physical and psychological demands on elite-level athletes, which can be a source of increased levels of stress. Therefore, high-level volleyball players may present altered cardiovascular and endocrinological stress response during stressful events. Although many previous studies have examined the response to stress on athletes, most of them regarded only males, while the impact of the female menstrual cycle has rarely been taken into account. We aimed to study psychophysiological response to anticipatory stressor through analysis of heart rate, self-reported anxiety level, and salivary cortisol in healthy young female athletes by minimalizing the effect of confounders. Materials and Methods: A total of 55 females (25 members of the best league for female volleyball players in Poland and 30 sedentary-lifestyle control subjects) in the follicular phase of their menstrual cycle were exposed to mental arithmetic tasks as an experimental imitation of the stressor. Volleyball players were significantly taller than sedentary individuals (177.1 ± 3.4 cm vs. 173.3 ± 3.4 cm, respectively, p = 0.034), but did not differ in weight (73.6 ± 5.2 kg vs. 70 ± 4.23 kg, respectively, p = 0.081), body mass index (BMI) (23.5 ± 1.13 vs. 24.1 ± 1.45, respectively, p = 0.060), and age (22 ± 1.11 vs. 23 ± 1.14 years, respectively, p = 0.2). Their stress responses were assessed through self-reported anxiety levels and physiological measurements of salivary cortisol concentrations and heart rate (HR). Results: For HR, significant effects of time (F(2,120) = 21.34, p < 0.001, η2 = 0.26) were found, but not for training status (F(1,60) = 2.69, p = 0.106, η2 = 0.04). For cortisol levels, the analysis showed the main effects of time (F(3,180) = 11.73, p < 0.001, η2 = 0.16) and training status (F(1,60) = 4.69, p = 0.034, η2 = 0.07) and a significant interaction between training status and time (F(3,180) = 3.07, p = 0.029, η2 = 0.05). Post-hoc analyses showed higher cortisol concentrations among volleyball players following the math task (all p < 0.001), as well as higher cortisol concentrations in S2, S3, and S4 compared to S1 in volleyball players (all p < 0.001). We observed also a significant increase in state anxiety in both groups (all p < 0.001), but no differences in state anxiety levels between groups. Conclusion: Female volleyball players may not differ in subjective graduation of stressors; however, exposure to training-based stressors seems to promote cortisol response to the anticipated stressor.
-
6.
Active Interest Mentorship for Soon-to-Retire People: A Self-Sustaining Retirement Preparation Program.
Ng, SM, Leng, L, Wang, Q
Journal of applied gerontology : the official journal of the Southern Gerontological Society. 2019;(3):344-364
Abstract
Retirement is a major life transition that often leads to maladjustments and mental health hazards. In this study, we developed an innovative retirement preparation program, the Active Interest Mentorship Scheme (AIMS), which utilized active interest development as a positive entry point through which to engage soon-to-retire people. Each retiree received a 1-year mentorship 6 months before retirement. Adopting a quasi-experimental design, the study aimed to evaluate the efficacy of the AIMS in protecting retirees' well-being. The well-being status of 161 retirees was assessed at 4-month intervals. Measures included self-esteem, life satisfaction, positive affect, depression, anxiety, and somatic symptoms. Serial trend analysis revealed a general improvement in well-being at 4 months after mentorship, followed by a mark reversion in some variables at 2 months after retirement. Upon completion of the program, participants generally returned to a level of well-being that was comparable with or better than preretirement levels. The first 2 months after retirement appeared to be the most distressing. The findings support the efficacy, as well as feasibility of the innovative retirement preparation program.
-
7.
Multi-modal prehabilitation: addressing the why, when, what, how, who and where next?
Scheede-Bergdahl, C, Minnella, EM, Carli, F
Anaesthesia. 2019;:20-26
-
-
Free full text
-
Abstract
Just as there is growing interest in enhancing recovery after surgery, prehabilitation is becoming a recognised means of preparing the patient physically for their operation and/or subsequent treatment. Exercise training is an important stimulus for improving low cardiovascular fitness and preserving lean muscle mass, which are critical factors in how well the patient recovers from surgery. Despite the usual focus on exercise, it is important to recognise the contribution of nutritional optimisation and psychological wellbeing for both the adherence and the response to the physical training stimulus. This article reviews the importance of a multi-modal approach to prehabilitation in order to maximise its impact in the pre-surgical period, as well as critical future steps in its development and integration in the healthcare system.
-
8.
Oxytocin reduces post-stress sweet snack intake in women without attenuating salivary cortisol.
Burmester, V, Gibson, EL, Butler, G, Bailey, A, Terry, P
Physiology & behavior. 2019;:112704
Abstract
Intranasal oxytocin produces anorectic effects on snack intake in men when tested in the absence of deprivation-induced hunger, but its effects on food intake in women without eating disorders have not been reported. Oxytocin may reduce food intake by reducing stress eating, since it inhibits ACTH release. The present study adopted a double-blind, repeated measures and fully concealed crossover protocol in which 38 women self-administered 24 IU of oxytocin or placebo intranasally, ate lunch, and underwent two consecutive stress tests. Snack intake was assessed 15-20 min after lunch, via a sham taste test. Salivary cortisol was measured throughout the test period every 15 min. Oxytocin significantly reduced sweet fatty snack intake independently of any effect on salivary cortisol, which declined over time at a similar rate after either drug or placebo. Ratings of sweet taste were slightly reduced by oxytocin, but only in self-reported stress eaters. These results differ from previous studies with men that found an effect of oxytocin on postprandial cortisol levels. However, previous research assayed the less active form of plasma cortisol and did not control for protein intake, which can drive elevated cortisol. The finding that oxytocin reduces snack intake in females after acute stress has important implications for appetite regulation and its treatment in obese people and in those with eating disorders.
-
9.
Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction.
Mocayar Marón, FJ, Ferder, L, Saraví, FD, Manucha, W
Stress (Amsterdam, Netherlands). 2019;(2):169-181
Abstract
Although a large number of available treatments and strategies, the prevalence of cardiovascular diseases continues to grow worldwide. Emerging evidence supports the notion of counteracting stress as a critical component of a comprehensive therapeutic strategy for cardiovascular disease. Indeed, an unhealthy lifestyle is a burden to biological variables such as plasma glucose, lipid profile, and blood pressure control. Recent findings identify allostatic load as a new paradigm for an integrated understanding of the importance of psychosocial stress and its impact on the development and maintenance of cardiovascular disease. Allostasis complement homeostasis and integrates behavioral and physiological mechanisms by which genes, early experiences, environment, lifestyle, diet, sleep, and physical exercise can modulate and adapt biological responses at the cellular level. For example, variability is a physiological characteristic of blood pressure necessary for survival and the allostatic load in hypertension can contribute to its related cardiovascular morbidity and mortality. Therefore, the current review will focus on the mechanisms that link hypertension to allostatic load, which includes psychosocial stress, inflammation, and mitochondrial dysfunction. We will describe and discuss new insights on neuroendocrine-immune effects linked to allostatic load and its impact on the cellular and molecular responses; the links between allostatic load, inflammation, and endothelial dysfunction; the epidemiological evidence supporting the pathophysiological origins of hypertension; and the biological embedding of allostatic load and hypertension with an emphasis on mitochondrial dysfunction.
-
10.
The stress and coping experiences among Chinese rural older adults in welfare housing: through the lens of life review.
Luo, Y, Sun, F, Jiang, L, Zhang, A
Aging & mental health. 2019;(9):1086-1094
Abstract
Purposes: Responding to the growing needs of the largest aging population in the world, China has been experimenting interventions introduced from other countries to serve its older citizens. Using the life review approach, this study aimed to understand stress and coping experiences of a group of rural older adults living in public welfare housing, and to identify the effect of life review on their perceptions of quality of life. Methods: This study used an experimental research design with qualitative interviews. Analyses mainly focused on qualitative interview data of participants in the experimental group (n=24). Quantitative analyses were conducted to compare changes in the measure of quality of life between the experimental group and the control group (n=22). Results: Qualitative analyses indicated that salient life course stressors among rural Chinese old adults included financial strains, health concerns, and loss of loved ones. Such stressors were intertwined with historical and social changes they experienced in China. Coping strategies developed to survive a harsh young adulthood were used to deal with aging challenges and adaption to the welfare housing. Quantitative analysis found those who went through life review reported significant improvement in perceived quality of life compared to the control group. Discussion: Life review showed preliminary acceptability and effectiveness among the most disadvantaged and marginalized older group in China. It suggests this approach can be adapted to help understand life experience of older adults from different socioeconomic and cultural backgrounds, and to bring about positive changes in their wellbeing.