1.
Topical Delivery of Modified Da-Cheng-Qi Decoction () Using Low-Frequency Ultrasound Sonophoresis for Refractory Metastatic Malignant Bowel Obstruction: An Open-Label Single-Arm Clinical Trial.
Tian, AP, Yin, YK, Yu, L, Yang, BY, Li, N, Li, JY, Bian, ZM, Hu, SY, Weng, CX, Feng, L
Chinese journal of integrative medicine. 2020;(5):382-387
Abstract
OBJECTIVE To evaluate the efficacy and safety of topical delivery of modified Da-Cheng- Qi Decoction (, MDCQD) by low-frequency ultrasound sonophoresis (LFUS) in patients with refractory metastatic malignant bowel obstruction (MBO) using an objective performance criteria (OPC) design. METHODS Fifty patients with refractory metastatic MBO were enrolled in this open-label single-arm clinical trial. Alongside fasting, gastrointestinal decompression, glycerol enema, intravenous nutrition and antisecretory therapy, a 50 g dose of MDCQD (prepared as a hydrogel) was applied through topical delivery at the site of abodminal pain or Tianshu (S 25) using LFUS for 30 min, twice daily for 5 consecutive days. The overall outcome was the remission of intestinal obstruction, and improvement on abdominal pain, abdominal distention, nausea and vomiting scores. Indicators of safety evaluation included liver and renal function as well as blood coagulation indicators. RESULTS Among 50 patients, 5 patients (10%) showed complete remission of intestinal obstruction and 21 patients (42%) showed improvement of intestinal obstruction. The overall remission rate of bowel obstruction was 52%. The results of the symptom score, based on the severity and frequency of the episode, are as follows: 26 patients (52%) showed improvment on symptom scores, 20 patients (40%) did not respond to treatment, and 4 patients (8%) discontinued treatment due to intolerance. No serious adverse effects or abnormal changes on liver and renal function or blood coagulation were observed. CONCLUSION Topical delivery of MDCQD at 100 g/day using LFUS can improve the treatment response in patients with refractory metastatic MBO.
2.
[Non-medication treatment of patients with chronic cystitis].
Karpukhin, IV, Kiiatkin, VA, Bobkov, AD
Voprosy kurortologii, fizioterapii, i lechebnoi fizicheskoi kultury. 2010;(6):33-5
Abstract
Combined application of ultrasound, modulated sinusoidal currents (MSC), and iodine-bromine baths is known to be a highly efficacious method for the rehabilitative treatment of patients with chronic cystitis in the phase of latent inflammation. The present study has demonstrated that combination of ultrasound with electrotherapeutic sleep and iodine-bromine baths exerts pronounced anti-inflammatory effect and bacteriostatic action whereas modulated sinusoidal currents combined with electrotherapeutic sleep and iodine-bromine baths significantly improve urodynamics in the lower urinary tract and produce marked anesthetic effect. Evaluation of the immediate and long-term results of the treatment of 16 patients presenting with chronic cystitis revealed the absence of exacerbation of infectious and inflammatory processes in the bladder within 6 months after physiotherapy
3.
High-intensity focused ultrasound for the treatment of liver tumours.
Kennedy, JE, Wu, F, ter Haar, GR, Gleeson, FV, Phillips, RR, Middleton, MR, Cranston, D
Ultrasonics. 2004;(1-9):931-5
Abstract
High-intensity focused ultrasound (HIFU) has been investigated as a tool for the treatment of cancer for many decades, but is only now beginning to emerge as a potential alternative to conventional therapies. In recent years, clinical trials have evaluated the clinical efficacy of a number of devices worldwide. In Oxford, UK, we have been using the JC HIFU system (HAIFU Technology Company, Chongqing, PR China) in clinical trials since November 2002. This is the first report of its clinical use outside mainland China. The device is non-invasive, and employs an extracorporeal transducer operating at 0.8-1.6 MHz (aperture 12-15 cm, focal length 9-15 cm), operating clinically at Isp (free field) of 5-15 KWcm(-2). The aims of the trials are to evaluate the safety and performance of the device. Performance is being evaluated through two parallel protocols. One employs radiological assessment of response with the use of follow-up magnetic resonance imaging and microbubble-contrast ultrasound. In the other, histological assessment will be made following elective surgical resection of the HIFU treated tumours. Eleven patients with liver tumours have been treated with HIFU to date. Adverse events include transient pain and minor skin burns. Observed response from the various assessment modalities is discussed.
4.
Postoperative pain in tonsillectomy: comparison of ultrasonic tonsillectomy versus blunt dissection tonsillectomy.
Sugiura, N, Ochi, K, Komatsuzaki, Y, Nishino, H, Ohashi, T
ORL; journal for oto-rhino-laryngology and its related specialties. 2002;(5):339-42
Abstract
Intraoperative blood loss, postoperative pain, and postoperative appetite were compared between 15 adult patients who underwent tonsillectomy using an ultrasonically activated scalpel (UT) and 15 adult patients who underwent blunt dissection tonsillectomy with cold steel instruments (BT). The average intraoperative blood loss of the UT group was 4.6 +/- 1.9 ml (mean +/- standard deviation), while that of BT group was 41.9 +/- 12.9 ml. This difference was highly statistically significant (p < 0.0001). In contrast, there were no significant differences in the VAS pain and appetite scores between patients who underwent UT and those who underwent BT on any day in the 6-day postoperative period. Our current results show that UT is a safe technique, and we believe that it should be considered a useful alternative for tonsil surgery.