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[Renal protective effects of benidipine and valsartan in primary hypertension patients with proteinuria].
Peng, T, Hu, Z, Guo, L, Yang, XD, Xia, Q, Li, XH, Jiang, B, Pei, F, Song, J
Zhonghua xin xue guan bing za zhi. 2010;(1):20-2
Abstract
OBJECTIVE To compare the renal protective effects between calcium channel blocker benidipine and angiotensin II receptor blocker valsartan in primary hypertension patients with proteinuria. METHODS A total of 236 patients were divided to low (< 1 g/24 h) and high (1 - 3 g/24 h) proteinuria groups and treated with benidipine (8 mg/d) or valsartan (80 mg/d) for 48 weeks. Blood pressure, glomerular filtration rate (GFR) and 24 h protein were measured at baseline, 12, 24 and 48 weeks. RESULTS Blood pressure was significantly and equally reduced in all treated groups (all P < 0.05 vs. baseline). GFR was also significantly and equally improved in all treated groups after 24 weeks treatments (all P < 0.05 at 24 weeks and 48 weeks). Proteinuria reduction at 24 and 48 weeks was more significant in patients treated with valsartan compared to patients treated with benidipine in low proteinuria group [24 weeks: (0.27 +/- 0.07) g/24 h vs. (0.39 +/- 0.06) g/24 h, P < 0.01; 48 weeks: (0.18 +/- 0.01) g/24 h vs. (0.30 +/- 0.05) g/24 h, P < 0.01]. CONCLUSION The renal protection efficacy of valsartan and benidipine was similar in primary hypertensive patients with proteinuria.