0
selected
-
1.
[Effect of a Physical Activity Promoting Program Based on the IMB Model on Obese-Metabolic Health Outcomes among Obese Older Adults with Knee Osteoarthritis].
Kim, JS, Kim, CJ
Journal of Korean Academy of Nursing. 2020;(2):271-285
Abstract
PURPOSE This study examined the effects of a physical activity promoting program based on the Information-Motivation-Behavioral Skills (IMB) model on physical activity and health outcomes among obese older adults with knee osteoarthritis. METHODS This study utilized a randomized controlled trial with a convenience sample of 75 obese older adults with knee osteoarthritis in a university hospital. The older adults in the intervention group participated in a 12-week program involving weekly group sessions and monitoring calls with education booklets and video clips for exercise dances, while those in the control group received an usual care. Outcomes were measured using self-report questionnaires, anthropometrics, and blood analyses. The intervention effects were analyzed using Mann-Whitney U test and ANCOVA. RESULTS The mean age of participants was 74.9 years with 84.0% women. The intervention group at 12 weeks showed significantly greater improvements in self-efficacy for physical activity (F=81.92, p<.001), physical activity amounts (Z=-2.21, p=.044), knee joint function (F=15.88, p<.001), and health-related quality of life (F=14.89, p<.001) compared to the control group. Among obese-metabolic outcomes, the intervention group at 12 weeks showed a significant decrease in visceral fat mass (F=7.57, p=.008) and improvement in high-density level cholesterol (F=9.51, p=.003) compared to the control group. CONCLUSION Study findings support the need for an IMB based physical activity program for promoting physical activity, knee function and health outcomes in obese older adults with knee osteoarthritis. Longitudinal studies are warranted to confirm the persistence of obese-metabolic effects in clinical settings.
-
2.
Alpine Skiing With total knee ArthroPlasty (ASWAP): metabolism, inflammation, and skeletal muscle fiber characteristics.
Kristensen, M, Pötzelsberger, B, Scheiber, P, Bergdahl, A, Hansen, CN, Andersen, JL, Narici, M, Salvioli, S, Conte, M, Müller, E, et al
Scandinavian journal of medicine & science in sports. 2015;:40-8
Abstract
We investigated the effect of alpine skiing for 12 weeks on skeletal muscle characteristics and biomarkers of glucose homeostasis and cardiovascular risk factors. Twenty-three patients with a total knee arthroplasty (TKA) were studied 2.9 ± 0.9 years (mean ± SD) after the operation. Fourteen patients participated in the intervention group (IG) and nine in the control group (CG). Blood samples and muscle biopsies were obtained before (PRE) and 7.3 ± 0.8 days after (POST) the intervention, and blood samples again after a retention (RET) phase of 8 weeks. With skiing, glucose homeostasis improved in IG (decrease in fasting insulin, increase in muscle glycogen) but not in CG. Fiber type distribution and size, as well as capillary density and number of capillaries around the fibers (CAF), were not different between the operated and the non-operated leg in either group. The relative number of type I fibers increased with skiing in IG with no change in CG. Inflammatory biomarkers, plasma lipids, and mitochondrial proteins and activity did not change. Alpine skiing is metabolically beneficial and can be used as a training modality by elderly people with TKA.
-
3.
Double-blind placebo-controlled trial of hydroxytyrosol of Olea europaea on pain in gonarthrosis.
Takeda, R, Koike, T, Taniguchi, I, Tanaka, K
Phytomedicine : international journal of phytotherapy and phytopharmacology. 2013;(10):861-4
Abstract
Hydroxytyrosol is mainly found in olive leaves after hydrolysis of oleuropein and has anti-oxidant, anti-bacterial, and anti-inflammatory properties. The aim of this study was to investigate the effect of hydroxytyrosol for alleviating the pain in patients with gonarthrosis. We conducted a double-blind clinical trial in which hydroxytyrosol or placebo was administered to adult patients with gonarthrosis for 4 weeks. The group administered hydroxytyrosol showed significant improvement in the Japanese Orthopedic Association score (pain measurement index) and the visual analog scale score compared to the placebo group.
-
4.
A study on the efficacy of treatment with mud packs and baths with Sillene mineral water (Chianciano Spa Italy) in patients suffering from knee osteoarthritis.
Fraioli, A, Serio, A, Mennuni, G, Ceccarelli, F, Petraccia, L, Fontana, M, Grassi, M, Valesini, G
Rheumatology international. 2011;(10):1333-40
Abstract
Mud-bath therapy plays a primary role in the treatment and prevention of osteoarthritis that has been recognised since antiquity. Numerous studies have demonstrated its clinical benefits and its effects on inflammatory mediators (interleukins), the immune system, cenesthesic factors (endorphins), and the diencephalic–pituitary–adrenal axis. This study was conducted to assess the efficacy of mud-bath therapy with mineral water from the Sillene Spring at Italy’s Chianciano Spa in patients with osteoarthritis of the knee. Patients (n = 61) were divided into two groups. Group A underwent three cycles of mud-based spa therapy over a year’s time, whereas group B did not. Clinical conditions, visual analogue scale pain ratings, and Lequesne indexes of the two groups were compared. We also compared these same parameters in the patients of the two groups that were following the therapy with drugs and in the patients of the group A before and after spa treatment. The percentage of patients with no symptoms or mild symptoms was higher in group A than in group B. Within group A, this percentage was higher after treatment than before spa therapy. Even in the comparison between the patients of the two groups that were following the therapy with drug, the results was that in group A the percentage of patients with no symptoms or mild symptoms was higher than in group B. Statistical analyses based on various tests revealed that almost all these differences were highly significant. No adverse effects were observed in any of the patients in group A. In conclusion, the mud-bath therapy performed at Chianciano Spa with Sillene Spring water remarkably improved the clinical conditions of patients with knee arthritis and significantly reduces the frequency and severity of symptoms and the disability they cause.
-
5.
Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis--results of a cohort study with a control group.
Beer, AM, Wegener, T
Phytomedicine : international journal of phytotherapy and phytopharmacology. 2008;(11):907-13
Abstract
STUDY OBJECTIVE The examination of the effectiveness and tolerance of willow bark extract in patients with gonarthrosis and coxarthrosis compared to conventional therapies. METHODS In an open, multicentric observational study with reference treatment, 90 patients were treated with a standardised willow bark extract preparation, 41 patients with a standard therapy prescribed by a doctor and 8 patients with a combination of the two. After 3 and finally 6 weeks the effectiveness and tolerance were determined by the doctor (clinical findings, recording of adverse events, global tolerance) and by the patients (WOMAC questions concerning pain and stiffness, questions on general state of health). RESULTS A total of 88 patients in the willow bark group and 40 patients in the reference group completed the study. The doctors and patients judged the effectiveness in both groups to be comparable. After 6 weeks the effectiveness of the willow bark extract tended to be assessed as better than in the group undergoing conventional therapy. Also in the subgroup of chronically sick patients (>3 months), after 6 weeks the effectiveness of both forms of treatment was comparable; however, the effect was slower to set in the willow bark group than in the reference group. Doctors and patients assessed the tolerance of the willow bark extract to be better than the conventional therapy. Adverse effects of the drugs did not occur in the willow bark group; one case each of reflux symptoms occurred in the reference group and the CONCLUSIONS For treating mild or fairly severe cases of gonarthrosis and coxarthrosis the effect of willow bark extract is comparable to that of standard therapies, without the corresponding side effects having to be accepted.
-
6.
Fast T2 mapping of the patellar articular cartilage with gradient and spin-echo magnetic resonance imaging at 1.5 T: validation and initial clinical experience in patients with osteoarthritis.
Quaia, E, Toffanin, R, Guglielmi, G, Ukmar, M, Rossi, A, Martinelli, B, Cova, MA
Skeletal radiology. 2008;(6):511-7
Abstract
OBJECTIVE To evaluate the T2 mapping of patellar articular cartilage in patients with osteoarthritis using gradient and spin-echo (GRASE) magnetic resonance (MR) imaging. MATERIALS AND METHODS After the imaging of a phantom consisting of two sealed 50-ml test objects with different concentrations (30% and 90% weight/volume) of copper sulphate, the T2 mapping of patellar articular cartilage was performed in 35 patients (21 male and 14 female; mean age +/- SD 42+/-17 years) with moderate degree of patellar osteoarthritis. Turbo-spin-echo (TSE) (TR milliseconds/ minimum-maximum TE milliseconds 3,000/15-120; total acquisition time 5 min 52 s) and GRASE (TR milliseconds/ minimum-maximum TE milliseconds 3,000/15-120; total acquisition time 1 min 51 s) were employed. In each patient patellar cartilage was segmented at nine locations (three superior, three central, and three inferior) by manually defined regions of interest. T2 relaxation times were calculated using a linear fit applied to the logarithm of signal intensity decay. RESULTS In the phantom the T2 values measured by GRASE were similar to those measured by MR spectroscopy (test object 1: 48.1 ms vs 51 ms; test object 2: 66.8 ms vs 71 ms; P>0.05, Wilcoxon test). In patients GRASE and TSE-derived T2 values demonstrated good agreement (mean difference +/- SD, 1.81+/-3.63 ms). The within-patient coefficient of variation was 22% for TSE and 23% for GRASE. CONCLUSION Fast T2 mapping of the patellar articular cartilage can be performed with GRASE within a third of the time of that of standard sequences.
-
7.
[Effect of combined continued hormone replacement therapy on knee osteoarthritis symptom of postmenopausal women].
Song, YJ, Lin, SQ, Wu, ZH, Weng, XS, Qiu, GX, Chen, FL
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae. 2004;(5):571-5
Abstract
OBJECTIVE To study the effect of combined continued estrogen and progestin replacement therapy on knee osteoarthritis (OA) symptoms of postmenopausal women. METHODS Sixty-four postmenopausal women with radiological knee OA and symptoms aged 45-75 were divided into treatment group and control group. They were given estradiol velerate (E2V) 1.0 mg/d and medroxyprogestetone acetate (MPA) 2 mg/d (treatment group) or placebo (control group) for 6 months. Calcium 400 mg/d were given to all cases. Then 0-100 mm visual analon scale (VAS) was used to evaluate the severity of knee pain at baseline and after 1, 3, 6 month of treatment. RESULTS Significant differences on pain at night and tenderness around knee were seen in the treatment group compared with the control group after 1 months of treatment (P = 0.036 and 0.035, respectively). The improvement of pain at night, during walk and morning stiffness between the two groups showed significant difference after 6 months (P = 0.026, 0.027, and 0.011, respectively). CONCLUSION Combined estrogen and progestin replacement therapy can relieve the knee OA symptoms of postmenopausal women.
-
8.
Prospective comparison of sodium hyaluronate and hylan G-F 20 in a clinical practice: comment on the concise communication by Martens.
Brown, DJ, Wood, EV, Hannah, HM, Rao, VS, Teanby, D
Arthritis and rheumatism. 2004;(5):1697-8; author reply 1698