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CITRIS-ALI: How statistics were used to obfuscate the true findings.
Marik, PE, Payen, D
Anaesthesia, critical care & pain medicine. 2019;38(6):575-577
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Precision Nutrition and Metabolic Syndrome Management.
González-Muniesa, P, Martínez, JA
Nutrients. 2019;11(10)
Abstract
The journal NUTRIENTS published some time ago a special issue about "Precision Nutrition and Metabolic Syndrome Management", which included a series of articles about the role of bioactive compounds, amino acids/proteins and fatty acids for personalized nutritional applications [...].
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Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific association for the study of the liver (APASL): an update.
Sarin, SK, Choudhury, A, Sharma, MK, Maiwall, R, Al Mahtab, M, Rahman, S, Saigal, S, Saraf, N, Soin, AS, Devarbhavi, H, et al
Hepatology international. 2019;13(4):353-390
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Abstract
The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set up in 2004 on acute-on-chronic liver failure (ACLF) was published in 2009. With international groups volunteering to join, the "APASL ACLF Research Consortium (AARC)" was formed in 2012, which continued to collect prospective ACLF patient data. Based on the prospective data analysis of nearly 1400 patients, the AARC consensus was published in 2014. In the past nearly four-and-a-half years, the AARC database has been enriched to about 5200 cases by major hepatology centers across Asia. The data published during the interim period were carefully analyzed and areas of contention and new developments in the field of ACLF were prioritized in a systematic manner. The AARC database was also approached for answering some of the issues where published data were limited, such as liver failure grading, its impact on the 'Golden Therapeutic Window', extrahepatic organ dysfunction and failure, development of sepsis, distinctive features of acute decompensation from ACLF and pediatric ACLF and the issues were analyzed. These initiatives concluded in a two-day meeting in October 2018 at New Delhi with finalization of the new AARC consensus. Only those statements, which were based on evidence using the Grade System and were unanimously recommended, were accepted. Finalized statements were again circulated to all the experts and subsequently presented at the AARC investigators meeting at the AASLD in November 2018. The suggestions from the experts were used to revise and finalize the consensus. After detailed deliberations and data analysis, the original definition of ACLF was found to withstand the test of time and be able to identify a homogenous group of patients presenting with liver failure. New management options including the algorithms for the management of coagulation disorders, renal replacement therapy, sepsis, variceal bleed, antivirals and criteria for liver transplantation for ACLF patients were proposed. The final consensus statements along with the relevant background information and areas requiring future studies are presented here.
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Public Health Nutrition special issue on ultra-processed foods.
Kelly, B, Jacoby, E
Public health nutrition. 2018;21(1):1-4
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Plain language summary
Food processing-based classification systems have been increasingly acknowledged in reports and commentary from the World Health Organisation, Food and Agriculture Organization of the United Nations, and the Pan American Health Organization. The aim of this issue was to examine the role and utility of food processing-based classification systems in food and nutrition research and public policy. This issue shows that food processing-based classification systems: - offer possibilities for use in public policy as a way to define unhealthful dietary patterns. - may underpin other regulatory strategies for the prevention and control of obesity and diet-related non-communicable diseases by identifying unhealthful foods. - could also be applied in local planning regulations, where these seek to influence the availability or accessibility of foods in local environments Authors conclude that food processing-based classification systems have a great potential for wider application in food policy.