1.
[Multi-frequency low-dose intravenous iron on oxidative stress in maintenance hemodialysis patients].
Yin, L, Chen, X, Chen, J, Cheng, M, Peng, Y, Yang, L
Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. 2012;(8):844-8
Abstract
OBJECTIVE To investigate the effect of different intravenous iron treatment regimens on anemia and oxidative stress in maintenance hemodialysis (MHD) patients. METHODS A total of 58 MHD patients were randomly divided into a multi-frequency low-dose intravenous iron group (iron sucrose 25 mg, twice a week for 8 weeks, n=19), a less-frequency regular-dose intravenous iron group (iron sucrose 100 mg, once every two weeks for 8 weeks, n=19), and a non-iron group (n=20). Another 20 healthy people served as a control group (n=20). The changes of hemoglobin (Hb), hematocrit (HCT), serum ferritin (SF) and transferrin saturation (TSAT), as well as the oxidative stress parameters of malon-dialdehyde (MDA), superoxide dismutase (SOD) and myeloperoxidase (MPO) were detected before and after the treatment. RESULTS After 8 weeks, compared with the non-iron group, the levels of Hb, HCT, SF and TSAT in the two iron groups were significantly elevated (P<0.01), but there was no difference between the two iron groups (P>0.05). After the single dialysis, the two iron groups had higher level of serum MDA, MPO and lower level of serum SOD than that of the non-iron supplementation group (P<0.01). The multi-frequency low-dose intravenous iron group had lower level of serum MDA [(5.37 ± 0.73) nmol/mL vs (6.37±1.67) nmol/mL], MPO [(81.41±7.60) U/L vs (96.75±16.97) U/L] and higher level of serum SOD [(84.77 ± 14.02) U/mL vs (68.23 ± 4.90) U/mL] than that of the less-frequency regular-dose intravenous iron group. After 8 weeks, there was no significant difference between the two iron groups (P>0.05). CONCLUSION Multi-frequency low-dose intravenous iron can effectively improve anemia in MHD patients, whose acute oxidative stress is lower than that of less-frequency regular-dose intravenous iron, and is a relatively safe and effective intravenous iron treatment regimen.
2.
[Virus adsorption onto nano-sized iron oxides as affected by different background solutions].
Shen, LL, Zhao, BZ, Zhang, JB, Chen, J, Zheng, H
Huan jing ke xue= Huanjing kexue. 2010;(4):983-9
Abstract
Batch adsorption studies were conducted to investigate virus adsorption onto four commercial nanoparticles of iron oxide as affected by different background solutions, using bacteriophage phiX174 as virus indicator. When artificial ground water was used, the 4 studied nanoparticles showed high virus adsorption capacity, among which alpha-Fe2O3 was the most effective, with the adsorption percent reaching 100% at low initial virus concentration (i.e. 1E + 03 PFU x mL(-1)). Virus adsorption results were described using the Langmuir and Freundlich adsorption isotherms. The estimated adsorption parameters indicated the presence of multilayer adsorption and favorable adsorption. The adsorption percentage by the studied nanoparticles increased with decreasing virus initial concentration. Our results further showed that higher ionic strength of the background solution reduced the virus adsorption, indicating that electrostatic interaction likely dominated the virus adsorption. The presence of anions in the background solution reduced the virus adsorption, probably because of the competitive adsorption between the viruses and anions for sorption sites available, among which HPO4(2-) showed more reduced than HCO3(-). On the other hand, the presence of multivalent cations was favorable for virus adsorption, with bivalent cations (e.g. Ca2+ and Mg2+) showing more favorable than monovalent cations (e.g. Na+ and K+). Results of this study suggest that nanoparticles of iron oxide may be potentially useful for virus removal from infecting water, while other anions or cations in the water should be considered.