1.
The significance of plasma high density lipoprotein cholesterol (hdlc).
Gupta, S, Rajagopal, G
Nepal Medical College journal : NMCJ. 2007;(3):212-4
Abstract
High Density Lipoprotein (HDL) transports in plasma, phospholipids, cholesterol, and triacylglycerol. The cholesterol associated with HDL (HDLc) is cholesterol that is scavenged from peripheral tissues back to liver. The liver converts this cholesterol into bile acids, bile salts, and esterifies the rest and secretes them into bile. Low HDLc is a risk factor for atherogenesis. Higher levels of HDLc in plasma are therefore an index of safety from coronary heart disease and atherosclerosis. Regular physical exercise, and changes in life style like cessation of smoking, lowered alcohol consumption, modified dietary fat intake and certain medications can improve the level of HDLc in plasma.
2.
Effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer.
Gupta, S, Tandon, VR, Kapoor, B, Gupta, A, Gupta, GD, Khajuria, V
The Journal of the Association of Physicians of India. 2006;:183-6
Abstract
AIM: To evaluate the effects of tamoxifen therapy on plasma lipid profile in patients of breast cancer. METHOD A total of 55 postoperative patients of breast cancer were given tablet tamoxifen 20mg orally daily for 6 months. Estimation of plasma lipid by standard method was carried out in both pre-menopausal and postmenopausal new patients of early stage breast cancer at 0 day, 3rd month and 6th months of therapy. RESULTS Suggested that in pre-menopausal and postmenopausal patient's TC and LDL-c levels were reduced significantly, whereas, TG, VLDL-c and HDL-c were not altered. Comparison of the effects of tamoxifen in pre-menopausal and postmenopausal patients on lipid profile revealed that fall in TC and LDL-c was significantly higher at both 3 and 6 months in postmenopausal patients. CONCLUSION The study demonstrates that tamoxifen to favorably alter the markers of cardiovascular risk in both pre-menopausal and postmenopausal patients of breast cancer.