1.
Transient Receptor Potential Ankyrin 1 (TRPA1) Channel and Neurogenic Inflammation in Pathogenesis of Asthma.
Yang, H, Li, S
Medical science monitor : international medical journal of experimental and clinical research. 2016;:2917-23
Abstract
Asthma is characterized by airway inflammation, airway obstruction, and airway hyperresponsiveness (AHR), and it affects 300 million people worldwide. However, our current understanding of the molecular mechanisms that underlie asthma remains limited. Recent studies have suggested that transient receptor potential ankyrin 1 (TRPA1), one of the transient receptor potential cation channels, may be involved in airway inflammation in asthma. The present review discusses the relationship between TRPA1 and neurogenic inflammation in asthma, hoping to enhance our understanding of the mechanisms of airway inflammation in asthma.
2.
TRP channels as drug targets.
Li, S, Westwick, J, Cox, B, Poll, CT
Novartis Foundation symposium. 2004;:204-13; discussion 213-21, 263-6
Abstract
Ca2+ channel antagonists acting on electrically-excitable cells have proved to be valuable therapeutic agents. The discovery of such agents and the identification of their molecular target resulted from the investigation of unexpected actions of known pharmacological agents. Ca2+ influx through receptor-operated channels in electrically non-excitable cells such as leukocytes is also functionally important, but to date the channels involved have not been successfully exploited as drug targets for anti-inflammatory therapy. Until recently, research in this area has been hindered by the lack of obvious molecular identity, but the emergence of the transient receptor potential (TRP) cation family has yielded promising candidates which may underpin the different receptor-operated Ca2+ influx pathways present in leukocytes. In addition, receptor-operated Ca2+ influx channels are also expressed in electrically-excitable cells suggesting that receptor-operated Ca2+ entry pathways are likely to be of wider significance and emphasizes the breadth of their potential as novel, and as yet, unexplored and unexploited drug targets.