1.
Thioether-derived Macrocycle for Peptide Secondary Structure Fixation.
Tian, Y, Yang, D, Ye, X, Li, Z
Chemical record (New York, N.Y.). 2017;(9):874-885
Abstract
Recently, we developed methods to stabilize peptides into various secondary structures, including α-helix, type III turn and β-hairpin via proper thioether based macrocyclization. These conformationally constrained peptidomimetics confer enhanced biophysical properties and provide a valuable avenue towards clinically-relevant therapeutic molecules. In this personal account, thioether-derived macrocyclization methods developed by our group for stabilization of α-helix, type-III β turn and β-hairpin conformations are discussed.