1.
Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles.
Wang, X, Cheng, W, Yang, Q, Niu, H, Liu, Q, Liu, Y, Gao, M, Xu, M, Xu, A, Liu, S, et al
Journal of environmental sciences (China). 2018;:217-226
Abstract
As well-known persistent organic pollutants (POPs), organofluorine pollutants such as perfluorooctane sulfonate (PFOS) have been proven to be bioaccumulated and harmful to health. However, toxicological assessment of organofluorinated nanoparticles, which have emerged as a novel tool for biomedical and industrial applications, is lacking, to the best of our knowledge. To assess the biological effects and health risk of fluorinated nanoparticles, trifluoroethyl aryl ether-based fluorinated poly(methyl methacrylate) nanoparticles (PTFE-PMMA NPs) were synthesized with various fluorine contents (PTFE-PMMA-1 NPs 12.0wt.%, PTFE-PMMA-2 NPs 6.1wt.% and PTFE-PMMA-3 NPs 5.0wt.%), and their cytotoxicity was investigated in this study. The in vitro experimental results indicated that the cytotoxicity of PTFE-PMMA NPs was mild, and was closely related to their fluorine (F) contents and F-containing side chains. Specifically, the cytotoxicity of PTFE-PMMA NPs decreased with increasing F content and F-containing side chains. After exposure to PTFE-PMMA NPs at a sublethal dose (50μg/mL) for 24hr, the phospholipid bilayer was damaged, accompanied by increasing permeability of the cell membrane. Meanwhile, the intracellular accumulation of reactive oxygen species (ROS) occurred, resulting in the increase of DNA damage, cell cycle arrest and cell death. Overall, the PTFE-PMMA NPs were found to be relatively safe compared with typical engineered nanomaterials (ENMs), such as silver nanoparticles and graphene oxide, for biomedical and industrial applications.
2.
Fabrication of Stabilized Fe⁻Mn Binary Oxide Nanoparticles: Effective Adsorption of 17β-Estradiol and Influencing Factors.
Ning, Q, Yin, Z, Liu, Y, Tan, X, Zeng, G, Jiang, L, Liu, S, Tian, S, Liu, N, Wang, X
International journal of environmental research and public health. 2018;(10)
Abstract
Fe⁻Mn binary oxide nanoparticles (FMBON) were reported to be high performance as adsorbent for pollutants removal from aqueous solution. However, there are still limitations in practice application due to the FMBON tend to aggregate into the micro millimeter level. In order to avoid the agglomeration of nanoparticles, this work synthesized the stabilized Fe⁻Mn binary oxide nanoparticles (CMC-FMBON) by using water-soluble carboxymethyl celluloses (CMC) as the stabilizer. The characteristics of CMC-FMBON and FMBON were measured by using Transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and Zeta potential. This work systematically investigated the adsorption capacity of CMC-FMBON for 17β-estradiol (E2) and the influences of external environmental factors on E2 removal. The results indicated that CMC-FMBON had much smaller particles, wider dispersion and larger surface area than the FMBON. CMC-FMBON showed better adsorption performance for E2 than FMBON with the maximum adsorption capacity of CMC-FMBON and FMBON were 124.10 and 98.14 mg/g at 298 K, respectively. The experimental data can be well fitted by the model of pseudo-second-order and Langmuir model. The E2 removal by CMC-FMBON was obviously dependent on pH with the maximum adsorption occurring when the pH was acidic. The removal capacity of CMC-FMBON increased when enhancing ionic strength in solution. Background electrolytes promoted slightly E2 adsorption process whereas the presence of humic acid inhibited the E2 removal. π-π interactions, hydrogen bonds, and oxidation might be responsible for E2 removal. This research suggested that the CMC-FMBON has been considered to be a cost-efficient adsorbent for removing E2 from water.