1.
Additional renoprotective effects of azelnidipine combined with angiotensin receptor blockers in patients with diabetic nephropathy.
Nakamura, T, Inoue, T, Fujiwara, N, Kawagoe, Y, Sugaya, T, Ueda, Y, Koide, H, Node, K
Clinical nephrology. 2008;(5):385-92
Abstract
Azelnidipine has been reported to have antioxidant effects and attenuates tubulointerstitial ischemia. The aim of the present study was to determine whether azelnidipine exerts additional renoprotective effects to angiotensin II receptor blockers (ARBs) in hypertensive patients with diabetic nephropathy and microalbuminuria. 45 hypertensive patients with diabetes mellitus and microalbuminuria who were already being treated with ARBs were enrolled in this study. Azelnidipine was added to the drug treatment of 30 patients (8 mg/day, n = 15, or 16 mg/day, n = 15) whilst the remaining 15 control patients were not treated with azelnidipine. In all patients, urinary 8-hydroxydeoxyguanosine (8-OHdG) levels and urinary liver-type fatty acid-binding protein (L-FABP) levels were significantly correlated (r = 0.587, p = 0.0006). However, urinary albumin excretion (UAE) was not correlated with the levels of urinary 8-OHdG (r = 0.1975, p = 0.2956) or urinary L-FABP (r = 0.2057, p = 0.2759). Azelnidipine significantly reduced UAE, urinary 8-OHdG and urinary L-FABP after 6 (p < 0.05) and 12 months (p < 0.05). Although blood pressure was comparable between the azelnidipine doses of 8 and 16 mg/day, the UAE (p < 0.05 after 12 months), urinary 8-OHdG (p < 0.05 after 6 and 12 months) and urinary L-FABP (p < 0.05 after 6 and 12 months) levels were more significantly reduced in patients receiving the higher dose of 16 mg/day. These data may suggest that the addition of azelnidipine treatment to therapy with ARBs has dose-dependent antioxidant and renoprotective effects beyond blood pressure-lowering effects in hypertensive diabetic nephropathy patients.
2.
[Effects of dopamine and dobutamine on renal function and urinary excretion of prostaglandin E2 in elderly postoperative patients].
Niiya, S, Fukusaki, M, Nakamura, T, Miyoshi, H, Ogata, K, Miyako, M
Masui. The Japanese journal of anesthesiology. 2001;(2):122-6
Abstract
Effects of dopamine and dobutamine on renal function and urinary excretion of prostaglandin E2 (UPGE) were studied in 21 elderly patients who underwent abdominal surgery. Fractional sodium excretion (FeNa), creatinine clearance (Ccr), urinary volume (UV, ml.kg-1.min-1) and UPGE were measured on the first and second postoperative day. These patients were divided into three groups: i.e. C (control), DA (dopamine) and DB (dobutamine) groups. Group DA received dopamine 2 mcg.kg-1.min-1 beginning at six o'clock on the first postoperative day. Group DB received dobutamine 2 mcg.kg-1.min-1. There were no significant differences in UV and UPGE among these three groups. Ccr was significantly higher on the second postoperative day than that on the first postoperative day in DA group. FeNa in DA group was higher than in C group on the second postoperative day. The relationship between UPGE and UV was not determined. These results suggest that DA improve renal functions in the elderly.