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Duration of Breastfeeding and Early Growth: A Systematic Review of Current Evidence.
Patro-Gołąb, B, Zalewski, BM, Polaczek, A, Szajewska, H
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine. 2019;(4):218-229
Abstract
Introduction: Growth patterns of breastfed and formula-fed infants differ, but the influence of breastfeeding duration on early growth remains unclear. The objective of this study is to evaluate current evidence on the association of exclusive and partial breastfeeding duration with different growth parameters during infancy. Materials and Methods: In this systematic review, we searched MEDLINE, EMBASE, and additional sources from January 2011 until March 2018 to identify relevant cohort studies and randomized controlled trials (RCTs). Results: Twenty studies that recruited infants from the general population were included. In the developed setting, exclusive breastfeeding duration was inversely associated with weight and length gain during infancy in observational studies. Longer duration of exclusive breastfeeding was also associated with an earlier peak in infant body mass index (BMI). Inconsistent results were observed for the associations of exclusive breastfeeding duration with other infant BMI characteristics. In an RCT conducted in Iceland, exclusive breastfeeding for 4 versus 6 months did not affect infant growth patterns. In the developing setting, conflicting findings on the associations of exclusive breastfeeding duration with infant weight and length parameters were shown in observational studies. Shorter partial breastfeeding duration was associated with higher weight gain during infancy, with limited or inconclusive data regarding other growth parameters. Conclusions: Longer duration of exclusive and partial breastfeeding tended to be associated with slower growth rates during infancy in the developed setting only. These associations seem to be dose dependent and more pronounced in exclusively versus partially breastfed infants.
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Systematic Review: Early Infant Feeding and the Risk of Type 1 Diabetes.
Pieścik-Lech, M, Chmielewska, A, Shamir, R, Szajewska, H
Journal of pediatric gastroenterology and nutrition. 2017;(3):454-459
Abstract
BACKGROUND In addition to genetic background, a number of environmental factors have been claimed to influence the development of type 1 diabetes (T1D), including infant diet. OBJECTIVE The aim of the study was to systematically update evidence on the possible relation between early feeding practices and the risk of T1D. METHODS The Cochrane Library, MEDLINE, EMBASE, Web of Science, and CINAHL were searched for studies of any design up to July 2015. MEDLINE and EMBASE were additionally searched in March 2016. The primary outcome measures were the development of T1D or T1D-associated autoimmunity (T1DA). RESULTS Nine publications were identified. Breastfeeding at the time of gluten introduction, as compared to gluten introduction after weaning, did not reduce the risk of developing T1DA or T1D. In children at high risk of developing T1D, except for gluten introduction at 3 months or younger age compared with gluten introduction at older than 3 months, which increased the risk of T1DA, the age of gluten introduction in infants had no effect on the risk of developing T1DA. CONCLUSIONS Current evidence, mainly from observational studies, does not support the claim that early infant feeding practices, such as breastfeeding at gluten introduction or the age of the infant at the time of gluten introduction, may decrease the risk of developing T1D. More robust data are needed from randomized controlled trials.
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Primary Prevention of Celiac Disease: Environmental Factors with a Focus on Early Nutrition.
Chmielewska, A, Pieścik-Lech, M, Szajewska, H, Shamir, R
Annals of nutrition & metabolism. 2015;:43-50
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Abstract
Celiac disease (CD) is a common autoimmune disorder caused by ingestion of gluten. When diagnosed, it should be treated with a lifelong, strict gluten-free diet. Early infant feeding practices have been suggested as a means of preventing CD. In the last few decades, observational data have suggested that breastfeeding, especially at the time of introducing gluten into the infant's diet, as well as the time and mode of gluten first being given to a child could prevent or delay the occurrence of CD. As a result, recommendations advised that it is prudent to avoid both early (<4 months) and late (>7 months) introduction of gluten, and to introduce gluten gradually while the infant is still being breastfed, as this may reduce the risk of celiac disease, type 1 diabetes mellitus, and wheat allergy. Recently, the results of two large randomized trials have shown that breastfeeding in general, breastfeeding during gluten introduction, and early or delayed gluten introduction do not influence the total risk of CD in genetically predisposed individuals. Introducing gluten at 4 versus 6 months in very small amounts, or at 6 versus 12 months, resulted in similar rates of CD in these children. Thus, early feeding practices seem to have no impact on the risk of developing CD during childhood. In children without the genetic predisposition, the age and mode of gluten introduction do not influence the risk anyway.
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Systematic review: early infant feeding and the prevention of coeliac disease.
Szajewska, H, Chmielewska, A, Pieścik-Lech, M, Ivarsson, A, Kolacek, S, Koletzko, S, Mearin, ML, Shamir, R, Auricchio, R, Troncone, R, et al
Alimentary pharmacology & therapeutics. 2012;(7):607-18
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Abstract
BACKGROUND PREVENTCD, Prevent Coeliac Disease, is an international project investigating the hypothesis of possible induction of tolerance to gluten in genetically predisposed children through introducing small quantities of gluten during the period of breastfeeding. AIM: To summarise current knowledge on the possible relationship between early feeding practices and the risk of coeliac disease (CD). METHODS The Cochrane Library, MEDLINE, and EMBASE databases were searched in May 2011, and the search was updated in January 2012, and again in July 2012. RESULTS Breastfeeding (BF) and CD: some studies show a protective effect of BF, while others show no effect. No studies have shown a long-term preventive effect. BF at the time of gluten introduction and CD: Results from a meta-analysis of five observational case-control studies suggest that BF at gluten introduction is associated with a lower risk of CD compared with formula feeding. It is unclear whether BF provides a permanent protection or only delays the onset of CD. Timing of gluten introduction: The data suggest that both early (≤4 months) and late (≥7 months) introduction of gluten may increase the risk of CD. Amount of gluten at weaning (and later) and CD: One incident case-referent study documented that the introduction of gluten in large amounts compared with small or medium amounts increased the risk of CD. CONCLUSIONS In the absence of clear evidence, in order to decrease the risk of later coeliac disease, it is reasonable to avoid both early (<4 months) and late (≥7 months) introduction of gluten, and to introduce gluten while the infant is still being breastfed. Future studies may clarify the remaining uncertainties.