1.
Imaging Bone-Cartilage Interactions in Osteoarthritis Using [18F]-NaF PET-MRI.
Savic, D, Pedoia, V, Seo, Y, Yang, J, Bucknor, M, Franc, BL, Majumdar, S
Molecular imaging. 2016;:1-12
Abstract
PURPOSE Simultaneous positron emission tomography-magnetic resonance imaging (PET-MRI) is an emerging technology providing both anatomical and functional images without increasing the scan time. Compared to the traditional PET/computed tomography imaging, it also exposes the patient to significantly less radiation and provides better anatomical images as MRI provides superior soft tissue characterization. Using PET-MRI, we aim to study interactions between cartilage composition and bone function simultaneously, in knee osteoarthritis (OA). PROCEDURES In this article, bone turnover and remodeling was studied using [18F]-sodium fluoride (NaF) PET data. Quantitative MR-derived T1ρ relaxation times characterized the biochemical cartilage degeneration. Sixteen participants with early signs of OA of the knee received intravenous injections of [18F]-NaF at the onset of PET-MR image acquisition. Regions of interest were identified, and kinetic analysis of dynamic PET data provided the rate of uptake ( Ki) and the normalized uptake (standardized uptake value) of [18F]-NaF in the bone. Morphological MR images and quantitative voxel-based T1ρ maps of cartilage were obtained using an atlas-based registration technique to segment cartilage automatically. Voxel-by-voxel statistical parameter mapping was used to investigate the relationship between bone and cartilage. RESULTS Increases in cartilage T1ρ, indicating degenerative changes, were associated with increased turnover in the adjoining bone but reduced turnover in the nonadjoining compartments. Associations between pain and increased bone uptake were seen in the absence of morphological lesions in cartilage, but the relationship was reversed in the presence of incident cartilage lesions. CONCLUSION This study shows significant cartilage and bone interactions in OA of the knee joint using simultaneous [18F]-NaF PET-MR, the first in human study. These observations highlight the complex biomechanical and biochemical interactions in the whole knee joint in OA, which potentially could help assess therapeutic targets in treating OA.
2.
[Clinical observation on treatment of primary knee osteoarthritis of liver and kidney deficiency type with Aconite cake-separated moxibustion].
Sun, K, Yang, J, Shen, DK
Zhongguo zhen jiu = Chinese acupuncture & moxibustion. 2008;(2):87-90
Abstract
OBJECTIVE To observe the effect of Aconite cake-separated moxibustion on primary knee osteoarthritis of liver and kidney deficiency type. METHODS Fifty-six cases of such disease (80 knees) were randomly divided into a cake-separated moxibustion group (41 knees) with Neixiyan (EX-LE 5), Dubi (ST 35), Yinlingquan (SP 9) etc. selected, and a western medicine group (39 knees) were treated with oral administration of Sodium Diclofenate Slow-released Tablet. RESULTS The cumulative score for symptoms and signs was (37.41 +/- 6.61) points before treatment and (9.37 +/- 8.15) points after treatment in the cake-separated moxibustion group and (37.64 - 6.00) points before treatment and (12.05 +/- 8.83) points after treatment in the western medicine group, with a very significant difference before and after treatment in the two groups (P < 0.01); two months after treatment, it was (11.71 +/- 8.69) points in the cake-separated moxibustion group and (15.95 +/- 9.96) points in the western medicine group, the former being better than the latter (P < 0.05). After the end of treatment, there was no significant difference in the comprehensive therapeutic effect between the two groups (P > 0.05), the cured and markedly effective rate was 63.4% in the cake-separated moxibustion group and 48.7% in the western medicine group, but two months after treatment, the cured and markedly effective rate of 56.1% in the cake-separated moxibustion group was better than 33.3% in the western medicine group (P < 0.05). CONCLUSION Aconite cake-separated moxibustion has an ideal therapeutic effect on primary knee osteoarthritis of liver and kidney deficiency type, and the therapeutic effect at anaphase is better than that of Sodium Diclofenate Slow-released Tablet.