1.
Prognostic significance and therapeutic option of heart rate variability in chronic kidney disease.
Zhang, J, Wang, N
International urology and nephrology. 2014;(1):19-25
Abstract
Cardiovascular disease (CVD) begins early in the course of chronic kidney disease (CKD) and is the leading cause of death in patients with CKD. Preventing the development of CVD and establishing new clinical tools for identifying high-risk individuals, particularly those with an increased risk for cardiac death, is of clinical importance. Abnormality of heart rate variability (HRV) has been shown to be associated with CVD and CKD. Assessment of HRV is based on analysis of consecutive normal R-R intervals and may provide quantitative information on the modulation of cardiac vagal and sympathetic nerve input. In this brief manuscript, increased CVD risk among CKD patients, mechanisms due to autonomic nerves dysfunction, changes of HRV and potential measures to ameliorate clinical prognostic of CKD patients will be discussed.
2.
Dynamic infrared imaging for analysis of fingertip temperature after cold water stimulation and neurothermal modeling study.
Zhang, HD, He, Y, Wang, X, Shao, HW, Mu, LZ, Zhang, J
Computers in biology and medicine. 2010;(7):650-6
Abstract
The human hand is considered to be the terminus of the nervous system. It contains numerous capillary vessels, and it plays an important role in the regulation of the autonomic nervous system. We have used infrared thermography and ultrasound Doppler flowmetry to investigate characteristics of the temperature variation of the hand and the blood flow after cold stimuli. We have also developed an image processing algorithm to measure temperature of various parts of the hand via sequential thermal images. Measured results show that local cold stimuli will induce oscillation of temperature, which may be due to neuroregulation during rewarming. Finally, in order to explain the mechanism of autonomic nervous system (ANS) regulation we have developed an ANS regulation model on the basis of the knowledge of the physiology and bioheat transfer. The results computed using our model are in good agreement with the experimental results.