1.
Potential molecular mechanisms underlying the effect of arsenic on angiogenesis.
Zhang, J, Zhang, Y, Wang, W, Zhang, Z
Archives of pharmacal research. 2019;(11):962-976
Abstract
Arsenic is a potent chemotherapeutic drug that is applied as a treatment for cancer; it exerts its functions through multiple pathways, including angiogenesis inhibition. As angiogenesis is a critical component of the progression of many diseases, arsenic is a feasible treatment option for patients with other angiogenic diseases, including rheumatoid arthritis and psoriasis, among others. However, arsenic is also a well-known carcinogen, demonstrating a pro-angiogenesis effect. This review will focus on the dual effects of arsenic on neovascularization and the relevant mechanisms underlying these effects, aiming to provide a rational understanding of arsenic treatment. In particular, we expect to provide a comprehensive overview of the current knowledge of the mechanisms by which arsenic influences angiogenesis.
2.
[Research advances of platelet derived growth factor family and its significance in neovascular eye diseases].
Bo, Q, Zhang, Y, Wu, Y, Wang, F
[Zhonghua yan ke za zhi] Chinese journal of ophthalmology. 2014;(6):471-5
Abstract
Platelet derived growth factor (PDGF) is a family of peliotropic growth factors that regulate cell proliferation and differentiation in an autocrine or paracrine manner through receptor mediated signal transduction pathways. Recent studies have demonstrated that PDGF plays an important role in ocular neovascularization, and the application of PDGF has a broad prospect in treatment of ocular neovascularization. Here, we summarize the current understanding of structure, function and expression of PDGF in the eye; the effects of PDGF on the blood vessel forming cells, as well as the interaction between PDGF and other pro-angiogenic factors. In addition, the role of PDGF in neovascular eye diseases, including retinopathy of prematurity, diabetic retinopathy, age-related macular degeneration, corneal neovascularization, and neovascular glaucoma, is also discussed.