1.
Endothelial Dysfunction in Diabetic Retinopathy.
Gui, F, You, Z, Fu, S, Wu, H, Zhang, Y
Frontiers in endocrinology. 2020;:591
Abstract
Diabetic retinopathy (DR) is a diabetic complication which affects retinal function and results in severe loss of vision and relevant retinal diseases. Retinal vascular dysfunction caused by multifactors, such as advanced glycosylation end products and receptors, pro-inflammatory cytokines and chemokines, proliferator-activated receptor-γ disruption, growth factors, oxidative stress, and microRNA. These factors promote retinal endothelial dysfunction, which results in the development of DR. In this review, we summarize the contributors in the pathophysiology of DR for a better understanding of the molecular and cellular mechanism in the development of DR with a special emphasis on retinal endothelial dysfunction.
2.
Metabolic signalling and carbon partitioning: role of Snf1-related (SnRK1) protein kinase.
Halford, NG, Hey, S, Jhurreea, D, Laurie, S, McKibbin, RS, Paul, M, Zhang, Y
Journal of experimental botany. 2003;(382):467-75
Abstract
A protein kinase that plays a key role in the global control of plant carbon metabolism is SnRK1 (sucrose non-fermenting-1-related protein kinase 1), so-called because of its homology and functional similarity with sucrose non-fermenting 1 (SNF1) of yeast. This article reviews studies on the characterization of SnRK1 gene families, SnRK1 regulation and function, interacting proteins, and the effects of manipulating SnRK1 activity on carbon metabolism and development.