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[Meta-analysis of vitamin C, vitamin E and β-carotene levels in the plasma of Alzheimer's disease patients].
Dong, R, Yang, Q, Zhang, Y, Li, J, Zhang, L, Zhao, H
Wei sheng yan jiu = Journal of hygiene research. 2018;(4):648-654
Abstract
OBJECTIVE To systematically evaluate the levels of vitamin C, vitamin E and β-carotene in the plasma of Alzheimer's disease( AD) patients. METHODS In this study, literature of the levels of vitamin C, vitamin E and β-carotene in the plasma of AD patients were collected by retrieving the database of Pub Med, Science Direct, CNKI and Wan Fang( from they were built to July 2017). RESULTS Meta-analysis result showed that, compared with the control group, the level of vitamin E in the plasma of AD patients declined significantly( SMD =-1. 49 μmol/L, 95% CI-2. 08--0. 89 μmol/L, P <0. 001). However, no differences were determined in the levels of the plasma vitamin C and β-carotene between the two groups( vitamin C: SMD =-1. 43 μmol/L, 95% CI-3. 05-0. 19 μmol/L, P = 0. 083; β-carotene: SMD =-0. 61 μmol/L, 95% CI-1. 40-0. 18 μmol/L, P = 0. 131). CONCLUSION Increasing vitamin E level in the plasma through vitamin E riched diet may be useful to prevent AD. However it is not yet believed the benefical role on AD to increase vitamin C and β-carotene.