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Dietary Patterns, Carbohydrates, and Age-Related Eye Diseases.
Francisco, SG, Smith, KM, Aragonès, G, Whitcomb, EA, Weinberg, J, Wang, X, Bejarano, E, Taylor, A, Rowan, S
Nutrients. 2020;(9)
Abstract
Over a third of older adults in the U.S. experience significant vision loss, which decreases independence and is a biomarker of decreased health span. As the global aging population is expanding, it is imperative to uncover strategies to increase health span and reduce the economic burden of this age-related disease. While there are some treatments available for age-related vision loss, such as surgical removal of cataracts, many causes of vision loss, such as dry age-related macular degeneration (AMD), remain poorly understood and no treatments are currently available. Therefore, it is necessary to better understand the factors that contribute to disease progression for age-related vision loss and to uncover methods for disease prevention. One such factor is the effect of diet on ocular diseases. There are many reviews regarding micronutrients and their effect on eye health. Here, we discuss the impact of dietary patterns on the incidence and progression of age-related eye diseases, namely AMD, cataracts, diabetic retinopathy, and glaucoma. Then, we focus on the specific role of dietary carbohydrates, first by outlining the physiological effects of carbohydrates on the body and then how these changes translate into eye and age-related ocular diseases. Finally, we discuss future directions of nutrition research as it relates to aging and vision loss, with a discussion of caloric restriction, intermittent fasting, drug interventions, and emerging randomized clinical trials. This is a rich field with the capacity to improve life quality for millions of people so they may live with clear vision for longer and avoid the high cost of vision-saving surgeries.
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Effect of combining pre-exercise carbohydrate intake and repeated short sprints on the blood glucose response to moderate-intensity exercise in young individuals with Type 1 diabetes.
Soon, WHK, Guelfi, KJ, Davis, EA, Smith, GJ, Jones, TW, Fournier, PA
Diabetic medicine : a journal of the British Diabetic Association. 2019;(5):612-619
Abstract
AIMS: To determine whether pre-exercise ingestion of carbohydrates to maintain stable glycaemia during moderate-intensity exercise results in excessive hyperglycaemia if combined with repeated sprints in individuals with Type 1 diabetes. METHODS Eight overnight-fasted people with Type 1 diabetes completed the following four 40-min exercise sessions on separate days in a randomized counterbalanced order under basal insulinaemic conditions: continuous moderate-intensity exercise at 50% V˙O2 peak; intermittent high-intensity exercise (moderate-intensity exercise interspersed with 4-s sprints every 2 min and a final 10-s sprint); continuous moderate-intensity exercise with prior carbohydrate intake (~10 g per person); and intermittent high-intensity exercise with prior carbohydrate intake. Venous blood was sampled during and 2 h after exercise to measure glucose and lactate levels. RESULTS The difference in marginal mean time-averaged area under the blood glucose curve between continuous moderate-intensity exercise + prior carbohydrate and intermittent high-intensity exercise + prior carbohydrate during exercise and recovery was not significant [0.2 mmol/l (95% CI -0.7, 1.1); P = 0.635], nor was the difference in peak blood glucose level after adjusting for baseline level [0.2 mmol/l (95% CI -0.7, 1.1); P = 0.695]. The difference in marginal mean time-averaged area under the blood glucose curve between continuous moderate-intensity and intermittent high-intensity exercise during exercise and recovery was also not significant [-0.2 mmol/l (95% CI -1.2, 0.8); P = 0.651]. CONCLUSIONS When carbohydrates are ingested prior to moderate-intensity exercise, adding repeated sprints is not significantly detrimental to glycaemic management in overnight fasted people with Type 1 diabetes under basal insulin conditions.
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Is There an Optimal Diet for Weight Management and Metabolic Health?
Thom, G, Lean, M
Gastroenterology. 2017;(7):1739-1751
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Abstract
Individuals can lose body weight and improve health status on a wide range of energy (calorie)-restricted dietary interventions. In this paper, we have reviewed the effectiveness of the most commonly utilized diets, including low-fat, low-carbohydrate, and Mediterranean approaches, in addition to commercial slimming programs, meal replacements, and newly popularized intermittent fasting diets. We also consider the role of artificial sweeteners in weight management. Low-fat diets tend to improve low-density lipoprotein cholesterol the most, while lower-carbohydrate diets may preferentially improve triglycerides and high-density lipoprotein cholesterol. However, differences between diets are marginal. Weight loss improves almost all obesity-related co-morbidities and metabolic markers, regardless of the macronutrient composition of the diet, but individuals do vary in preferences and ability to adhere to different diets. Optimizing adherence is the most important factor for weight loss success, and this is enhanced by regular professional contact and supportive behavioral change programs. Maintaining weight losses in the long term remains the biggest challenge, and is undermined by an "obesogenic" environment and biological adaptations that accompany weight loss.
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Does Carbohydrate Intake During Endurance Running Improve Performance? A Critical Review.
Wilson, PB
Journal of strength and conditioning research. 2016;(12):3539-3559
Abstract
Wilson, PB. Does carbohydrate intake during endurance running improve performance? A critical review. J Strength Cond Res 30(12): 3539-3559, 2016-Previous review articles assessing the effects of carbohydrate ingestion during prolonged exercise have not focused on running. Given the popularity of distance running and the widespread use of carbohydrate supplements, this article reviewed the evidence for carbohydrate ingestion during endurance running. The criteria for inclusion were (a) experimental studies reported in English language including a performance task, (b) moderate-to-high intensity exercise >60 minutes (intermittent excluded), and (c) carbohydrate ingestion (mouth rinsing excluded). Thirty studies were identified with 76 women and 505 men. Thirteen of the 17 studies comparing a carbohydrate beverage(s) with water or a placebo found a between-condition performance benefit with carbohydrate, although heterogeneity in protocols precludes clear generalizations about the expected effect sizes. Additional evidence suggests that (a) performance benefits are most likely to occur during events >2 hours, although several studies showed benefits for tasks lasting 90-120 minutes; (b) consuming carbohydrate beverages above ad libitum levels increases gastrointestinal discomfort without improving performance; (c) carbohydrate gels do not influence performance for events lasting 16-21 km; and (d) multiple saccharides may benefit events >2 hours if intake is ≥1.3 g·min Given that most participants were fasted young men, inferences regarding women, adolescents, older runners, and those competing in fed conditions are hampered. Future studies should address these limitations to further elucidate the role of carbohydrate ingestion during endurance running.
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Carbohydrate ingestion and soccer skill performance during prolonged intermittent exercise.
Ali, A, Williams, C
Journal of sports sciences. 2009;(14):1499-508
Abstract
The aim of this study was to investigate the effect of ingesting a carbohydrate-electrolyte solution, during the 90-min Loughborough Intermittent Shuttle Test, on soccer skill performance. Seventeen male soccer players ingested either a 6.4% carbohydrate-electrolyte solution or placebo solution equivalent to 8 ml . kg(-1) body mass before exercise and 3 ml . kg(-1) body mass after every 15 min of exercise, in a double-blind randomized cross-over design, with the trials separated by 7 days. The evening before the main trial, the participants performed glycogen-reducing exercise on a cycle ergometer (80 min at 70%[Vdot]O(2max)) and were then fed a low-carbohydrate meal. After a 12-h overnight fast, they performed The Loughborough Soccer Passing Test before and after every 15 min of exercise. Analysis of the combined skill test data showed a significant time effect (P = 0.001) with differences between 0-45 and 75-90 min (P < 0.05). There was a 3% reduction in skill performance from before to after exercise in the carbohydrate-electrolyte trial, whereas in the placebo trial the decrease was 14% (P = 0.07). In conclusion, skill performance during the simulated soccer activity appeared to deteriorate in the last 15-30 min of exercise. However, providing 52 g . h(-1) carbohydrate during exercise showed a tendency to better maintain soccer skill performance than a taste-matched placebo.
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The influence of carbohydrate-electrolyte ingestion on soccer skill performance.
Ali, A, Williams, C, Nicholas, CW, Foskett, A
Medicine and science in sports and exercise. 2007;(11):1969-76
Abstract
PURPOSE To investigate the effect of ingesting a carbohydrate-electrolyte solution (CHO-E), in subjects with reduced carbohydrate stores, during an intermittent shuttle running test (LIST) on soccer passing (LSPT) and shooting (LSST) performance. METHODS Sixteen healthy male university soccer players ingested either a 6.4% CHO-E or placebo (PLA) solution during 90 min of the LIST (5 mL x kg(-1) BM before and 2 mL x kg(-1) BM every 15 min of exercise), in a double-blind, randomized, crossover design, with each trial separated by at least 7 d. On the evening before the main trial (17:00 h), subjects performed the glycogen-reducing cycling exercise (approximately 80 min at 70% VO2max). They were then fed a low-carbohydrate evening meal and reported to the laboratory the following morning after a 10-h fast. Blood was collected at rest and after every 30 min of exercise; skill tests were performed before and after the LIST. RESULTS The change in mean LSST performance from pre- to post-LIST was better in the CHO-E trial (11 +/- 45 vs -16 +/- 42%; P < 0.01) but not significantly different for the LSPT performance (-1 +/- 10% (CHO-E) vs -6 +/- 13% (PLA), P = 0.13). Sprint performance during the LIST was quicker in the CHO-E trial (2.50 +/- 0.13 vs 2.53 +/- 0.13 s, P < 0.01). Plasma glucose was higher in the CHO-E trial after 90 min of exercise (5.2 +/- 0.3 vs 3.9 +/- 0.4 mM, P < 0.01). CONCLUSIONS Ingestion of a carbohydrate-electrolyte solution during exercise enabled subjects with compromised glycogen stores to better maintain skill and sprint performance than when ingesting fluid alone.