Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function.

1Division of Nutritional Sciences,Cornell University,Ithaca,NY 14853,USA. 2Department of Biostatistics,University of Washington,Seattle,WA 98195,USA. 4Department of Biomedical and Translational Informatics,Geisinger,Danville,PA 17822,USA. 6Icelandic Heart Association,Holtasmari 1, 201 Kópavogur,Iceland. 7Center for Public Health Genomics,University of Virginia School of Medicine,Charlottesville,VA 22903,USA. 8Department of Biostatistics,Boston University School of Public Health,Boston,MA 02118,USA. 9Department of Respiratory Medicine,Ghent University Hospital,9000 Ghent,Belgium. 11Division of Epidemiology and Community Health,University of Minnesota,Minneapolis,MN 55454,USA. 12Jean Mayer-US Department of Agriculture Human Nutrition Research Center on Aging,Tufts University,Boston,MA 02111,USA. 14Department of Medicine,University of Washington,Seattle,WA 98195,USA. 15Institute of Molecular Medicine,University of Texas Health Science Center at Houston,Houston,TX 77030,USA. 17Children's Nutrition Research Center,Baylor College of Medicine,Houston,TX 77030,USA. 5Department of Epidemiology,Gillings School of Global Public Health,University of North Carolina at Chapel Hill,Chapel Hill,NC 27599,USA. 19Laboratory of Epidemiology, Demography, and Biometry,National Institute on Aging,National Institutes of Health,Department of Health and Human Services, Bethesda,MD 20892,USA. 10Department of Epidemiology,Erasmus Medical Center,3000 CA Rotterdam,the Netherlands. 22Department of Nutrition and Nutrition Research Institute,University of North Carolina at Chapel Hill,Kannapolis,NC 28081,USA. 23Sticht Center on Aging,Wake Forest School of Medicine,Winston-Salem,NC 27157,USA. 26The Pulmonary Center,Department of Medicine,Boston University,Boston,MA 02118,USA. 3Cardiovascular Health Research Unit,University of Washington,Seattle,WA 98101,USA. 28Department of Medicine,Columbia University,New York,NY 10032,USA. 32Institute for Translational Genomics and Population Sciences,Los Angeles Biomedical Research Institute and Department of Pediatrics at Harbor-UCLA Medical Center,Torrance,CA 90502,USA. 33Division of Pulmonary and Critical Care,Feinberg School of Medicine,Northwestern University,Chicago,IL 60611,USA. 34Division of Cardiovascular Medicine,Department of Medicine,Vanderbilt University,Nashville,TN 37232,USA. 20Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging,2333 ZC Leiden,The Netherlands. 38Division of Intramural Research,National Institute of Environmental Health Sciences,National Institutes of Health, Department of Health and Human Services,Research Triangle Park,NC 27709,USA. 39Center for Omics Discovery and Epidemiology, Behavioral Health Research Division,RTI International,Research Triangle Park,NC 27709,USA.

The British journal of nutrition. 2018;(10):1159-1170

Abstract

The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)-pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D-pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (P race difference=0·56). Among EA, the 25(OH)D-FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.

Methodological quality

Publication Type : Meta-Analysis

Metadata

MeSH terms : Heart ; Lung