a Division of Cardiology, Department of Internal Medicine , Wan Fang Hospital, Taipei Medical University , Taipei City , Taiwan . b The VIP Department , Shanghai East Hospital, Tongji University School of Medicine , Shanghai , China. c Research Center for Translational Medicine , Shanghai East Hospital Affiliated to Tongji University School of Medicine , Shanghai , China. d Department of Medicine & Therapeutics , The Chinese University of Hong Kong , Shatin , Hong Kong. e Department of Cardiac Surgery , Shanghai East Hospital, Tongji University , Shanghai , China.