Department of Molecular, Cellular, and Developmental Biology, University of Michgan, Ann Arbor, MI, 48109, USA. Department of Molecular, Cellular, and Developmental Biology, University of Michgan, Ann Arbor, MI, 48109, USA; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI, 48109, USA. Electronic address: ujakob@umich.edu.