Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. Experimental Pathology and Therapeutics Group, IPO-Porto Research Center, Portuguese Institute of Oncology, Porto, Portugal. Institute of Biomedical Sciences Abel Salazar, University of Porto, Porto, Portugal. Porto Comprehensive Cancer Center (P.ccc), Porto, Portugal. Faculty of Health Sciences, University Fernando Pessoa (UFP), Porto, Portugal. Laboratory of Medical Investigation (LIM 14), Faculty of Medicine, São Paulo State University, São Paulo, Brazil. Molecular Oncology Research Center, Barretos Cancer Hospital, São Paulo, Brazil. Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho, Braga, Portugal. fbaltazar@med.uminho.pt. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimarães, Portugal. fbaltazar@med.uminho.pt.