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Breakthroughs in the Use of Inositols for Assisted Reproductive Treatment (ART).

Mother-Infant Department, University of Modena and Reggio Emilia, Modena, Italy. Systems Biology Laboratory, Department of Experimental Medicine, Sapienza University, Rome, Italy. Faculty of Medicine, University of Lille, and Institut National de la Santé et de la Recherche Médicale (INSERM) Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research Centre, Lille, France. Near East University, Faculty of Medicine, Department of Obstetrics and Gynecology, and Research Center of Experimental Health Sciences, Nicosia, Cyprus. Third Department of OB-GYNAE, Aristotle University of Thessaloniki, and IVF Laboratory, IAKENTRO Fertility Centre, Thessaloniki, Greece. National Council of Scientific and Technical Research, Instituto de Biología y Medicina Experimental (IBYME), Buenos Aires, Argentina. Diagnostic Techniques Unit, Medical University of Lublin, Poland. Department of Experimental Medicine, Sapienza University, Rome, Italy. Electronic address: vunfer@gmail.com.

Trends in endocrinology and metabolism: TEM. 2020;(8):570-579
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Abstract

It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). In addition, MI plays a pivotal role in the physiology of reproduction, and has beneficial effects on the development of oocytes, spermatozoa, and embryos. By contrast, DCI has little effect on spermatozoa, but high concentrations in the ovary can negatively affect the quality of oocytes and the blastocyst. Overall, the evidence in the literature supports the beneficial effects of MI in both female and male reproduction, warranting clinical use of MI in assisted reproductive treatment (ART).

Methodological quality

Publication Type : Review

Metadata

MeSH terms : Inositol