Public health crises, such as the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are severe traumatic events that impose threats both due to physical concerns and also psychological distress of infected patients. The aim of this study was to evaluate the efficacy of an internet-based integrated intervention on depression and anxiety symptoms in patients infected by SARS-CoV-2. The study is a prospective, randomized, controlled, 2-week study which enrolled 26 COVID-19 patients. Participants were randomly assigned to groups sequentially to either the intervention group or control group (n=13). Results indicate that patients of the intervention group exhibited significantly decreased levels of depression and anxiety symptoms in comparison with those of the control group. Authors conclude that an internet-based integrated intervention could be applied in the management of psychological distress in COVID-19 patients.