Department of Pharmacology and Toxicology, Faculty of Pharmacy and Center of Drug Discovery Research and Development, Ain Shams University, Cairo, 11566, Egypt. tolba.mf@pharma.asu.edu.eg. School of Life and Medical Sciences, University of Hertfordshire-Hosted By Global Academic Foundation, New Capital City, Egypt. tolba.mf@pharma.asu.edu.eg. Clinical Oncology Department, and Medical Research Center (MASRI), Faculty of Medicine, Ain Shams University, Cairo, Egypt. Department of Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Chapman University, Irvine, CA, USA. School of Pharmacy, Omar-Al-Mukhtar University, Derna, Libya. Department of Pharmacology and Toxicology, Faculty of Pharmacy, The British University in Egypt (BUE), 11837, El Sherouk City, Egypt. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, USA. Harvard Medical School, Boston, MA, USA.