The Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK. Electronic address: ldfc1n15@soton.ac.uk. Biological Sciences, Faculty of Environmental and Life Sciences, University of Southampton, Highfield Campus, Life Sciences Building 85, Southampton, SO17 1BJ, UK. MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK. The Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK; NIHR Southampton Biomedical Research Centre, University of Southampton and University Hospital Southampton NHS Foundation Trust, Southampton, SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom. The Institute of Developmental Sciences, University of Southampton, Southampton General Hospital, Southampton, SO16 6YD, UK; Institute for Life Sciences, University of Southampton, Southampton, United Kingdom.