Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University, Stanford, CA, USA. Department of Pharmacology, Arizona Health Sciences Center, University of Arizona, Tucson, AZ, USA. Department of Neurology, School of Medicine, Stanford University, Stanford, CA, USA. Exalys Therapeutics, Inc., San Diego, CA, USA. Thomas Jefferson University School of Medicine, Philadelphia, PA, USA.