Unique roles in health promotion of dietary flavonoids through gut microbiota regulation: Current understanding and future perspectives.

School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China; Department of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore. College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China. Electronic address: rzy0529@jmu.edu.cn. Department of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore. Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada. School of Grain Science and Technology, Jiangsu University of Science and Technology, Zhenjiang 212100, Jiangsu, China. State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China. College of Standardization, China Jiliang University, Hangzhou 310018, China. Zhejiang Provincial Key Lab of Geriatrics & Geriatrics Institute of Zhejiang Province, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China. Department of Food Science and Technology, National University of Singapore, Singapore 117542, Singapore. Electronic address: fstynghs@nus.edu.sg.

Food chemistry. 2023;:133959
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Abstract

Advances in understanding the biological effects of dietary flavonoids and flavonoid-rich foods have been reported. Improving knowledge about their beneficial effects, and mechanisms of action, is crucial for better utilization. However, mechanisms responsible for their health benefits are still unclear. Previous research considered has suggested that gut microbiota might be linked to the metabolism of dietary flavonoids. To understand the bioactivities of dietary flavonoids/flavonoid-rich foods better, and the role of microbiota, we explored systematically 1) types of dietary flavonoids and associated health benefits, 2) low bioaccessibilities and metabolic characteristics, 3) gut microbiota role in regulation, and 4) crosstalk between regulation mechanisms. Current challenges and future perspectives were also considered, offering new research directions and identifying trends in the development of flavonoid-rich food products.

Methodological quality

Publication Type : Review

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