0
selected
-
1.
[Effects of entecavir and Shenxian Yiganling combination therapy on patients with HBeAg-positive chronic hepatitis B for 48 weeks].
Zhang, T, Wang, Y, Sun, KW
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2012;(2):180-2
Abstract
OBJECTIVE To evaluate of the efficacy and safety of entecavir (ETV) combined with Shenxian Yiganling (SY) versus ETV therapy on patients with HBeAg-positive chronic hepatitis B (CHB) for 48 weeks. METHODS One hundred and sixty-four CHB patients were assigned to two groups with the cohort study: the ETV combined with SY treatment group and the ETV control group. The alanine aminotransferase (ALT), the undetectable HBV DNA level, and HBeAg negative conversion rate, and HBeAg serological negative conversion rate were observed before and after treatment. RESULTS At week 48, there was no significant difference in the normalization of ALT levels (70.00% vs 67.61%, P > 0.05) and undetectable HBV DNA levels (72.50% vs 73.24%, P > 0.05) between the two groups. There was significant difference in the HBeAg negative conversion rate (39.44% vs 23.75%) and HBeAg serological negative conversion rate (32.39% vs 15.00%) (both P < 0.05). CONCLUSION ETV combined with SY promoted the HBeAg serological negative conversion rate possibly through the recovery of the immune functions.
-
2.
[Clinical observation on effect of shenqi guchong recipe in treating peri-menopausal anovulatory dysfunctional uterine bleeding].
Ye, Q, Song, W, Zhang, LJ
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2010;(7):686-8
Abstract
OBJECTIVE To investigate the effect and hemostatic mechanism of Shenqi Guchong Recipe (SGR) in treating peri-menopausal anovulatory dysfunctional uterine bleeding (ADUB) of qi deficiency blood stasis syndrome type (QDBS). METHODS Patients of ADUB-QDBS were assigned to two groups, the 47 patients in the treated group administering orally with SGR and the 31 in the control group treated with Kunning Oral Liquid. The hemostatic effect, and the changes before and after treatment of 6-ketoprostaglandin 1alpha (6-K-PGF1 alpha), thromboxane B2(TXB2), T-lymphocyte subsets (CD3 and CD8, CD4/CD8 ratio) in menstrual blood, and serum calcium level in patients were observed. RESULTS The hemostatic effect in the treated group [85.1% (40/47)] was better than that in the control group [51.6% (16/31)], significant difference was shown between groups (P < 0.05). Changes of 6-K-PGF1 alpha TXB2, and 6-K-PGF1 alph/TXB2 ratio in the treated group were significant after treatment and showed significant difference as compared with those in the control group (P < 0.05 or P < 0.01). Meantime, serum Ca2+ level was increased and parameters of T-lymphocyte subsets improved significantly in the treated group (P < 0.05 or P < 0.01), also statistically different to those in the control group (P < 0.05). CONCLUSION SGR shows obvious hemostatic effect in treating patients with ADUB of QDBS type, and the mechanism may be related to its actions for improving microcirculation, enhancing immune function, and improving uterine local micro-environment, etc.
-
3.
[Effect of shenqi fuzheng injection on repairing the immune function in patients with breast cancer].
Li, HS, Yang, B, Su, XC
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2009;(6):537-9
Abstract
OBJECTIVE To investigate the effect and mechanism of Shenqi Fuzheng Injection (SFI) in repairing immune function of organism at cellular and molecular levels. METHODS Seventy-seven patients with pathologically confirmed diagnosis of breast cancer were assigned to three groups, the 22 patients in group A received surgical operation only; the 26 in group B were treated with surgical operation and chemotherapy; and to the 29 in group C, both chemotherapy and SFI were given after surgical operation. Besides, a group D with 22 patients with benign tumor was set up for control. The protein expressions of CD83, CD80 and CD86 in all patients' tumor tissue and axillary lymph node were detected by flow cytometry before and after treatment. RESULTS Levels of CD83, CD80 and CD86 in both tumor tissue and lymph node of cancer patients were significantly lower than those in the control (P < 0.05); and those in group B were significantly lower than in group A (P < 0.05, P < 0.01); but no significant difference was found in comparing the corresponding indices between group A and group C (P > 0.05). CONCLUSION The immune function of tumor patients could be impaired by tumor and chemotherapy definitely, and SFI could give aid to the repairing of immunity by way of participating in the activation of dendritic cells and the up regulation of co-stimulus molecules.
-
4.
Monitoring of immune responses to a herbal immuno-modulator in patients with advanced colorectal cancer.
Chen, X, Hu, ZP, Yang, XX, Huang, M, Gao, Y, Tang, W, Chan, SY, Dai, X, Ye, J, Ho, PC, et al
International immunopharmacology. 2006;(3):499-508
Abstract
Many herbal medicines are widely used as immuno-modulators in Asian countries. Ganoderma lucidum (Lingzhi) is one of the most commonly used herbs in Asia and preclinical studies have established that the polysaccharide fractions of G. lucidum have potent immuno-modulating effects. However, clinical evidence for this is scanty. The present open-labeled study aimed to evaluate the effects of G. lucidum polysaccharides on selected immune functions in patients with advanced colorectal cancer. Forty-seven patients were enrolled and treated with oral G. lucidum at 5.4 g/day for 12 weeks. Selected immune parameters were monitored using various immunological methods throughout the study. In 41 assessable cancer patients, treatment with G. lucidum tended to increase mitogenic reactivity to phytohemagglutinin, counts of CD3, CD4, CD8 and CD56 lymphocytes, plasma concentrations of interleukin (IL)-2, IL-6 and interferon (IFN)-gamma, and NK activity, whereas plasma concentrations of IL-1 and tumor necrosis factor (TNF)-alpha were decreased. For all of these parameters, no statistical significance was observed when a comparison was conducted between baseline and those values after a 12-week treatment with G. lucidum. The changes of IL-1 were correlated with those for IL-6, IFN-gamma, CD3, CD4, CD8 and NK activity (p<0.05) and IL-2 changes were correlated with those for IL-6, CD8 and NK activity. The results indicate that G. lucidum may have potential immuno-modulating effect in patients with advanced colorectal cancer. Further studies are needed to explore the benefits and safety of G. lucidum in cancer patients.
-
5.
Changes in serum tumor necrosis factor (TNF-alpha) with kami-shoyo-san administration in depressed climacteric patients.
Ushiroyama, T, Ikeda, A, Sakuma, K, Ueki, M
The American journal of Chinese medicine. 2004;(4):621-9
Abstract
An herbal medicine (kampo) is widely used to prevent or treat climacteric symptoms. In order to investigate the potential involvement of tumor necrosis factor (TNF)-alpha in susceptibility to mood disorder in climacteric women and to clarify the relationship between immune function and the efficacy of herbal medicine, we compared serum TNF-alpha levels in two treated groups, with and without concurrent use of herbal medicine. This study included 113 consecutive depressed menopausal patients who visited the gynecological and psychosomatic medicine outpatient clinic of the Osaka Medical College Hospital in Japan. Fifty-eight patients were administered kami-shoyo-san according to the definition of above sho. In contrast, 55 patients who were different in sho of kami-shoyo-san were administered antidepressants. Hamilton Rating Scale for depression (HAM-D) scores were determined at baseline and 12 weeks after starting treatment (endpoint). TNF-alpha concentrations were analyzed before and after 12 weeks of treatment. Kami-shoyo-san significantly increased plasma concentrations of TNF-alpha after 12 weeks of treatment, to 17.22 +/- 6.13 pg/ml from a baseline level of 14.16 +/- 6.27 pg/ml (p = 0.048). The percent change in plasma concentration of TNF-alpha differed significantly between the kami-shoyo-san therapy group and the antidepressant therapy group at 4 weeks (12.0 +/- 7.8% and -1.22 +/- 0.25%, respectively, p < 0.01), 8 weeks (19.7 +/- 3.4% and -2.45 +/- 0.86%, respectively, p < 0.01), and 12 weeks (21.3 +/- 5.4% and -6.81 +/- 2.2%, respectively, p < 0.001). We found in this study that kami-shoyo-san, an herbal medicine, increased plasma TNF-alpha levels in depressed menopausal patients. Cytokines may play various roles in mood and emotional status via the central nervous system and may be regulated by herbal medicines, although the interactions are very complex.
-
6.
[Controlled clinical study on 49 patients of SARS treated by integrative Chinese and Western medicine].
Zhang, RL, Jiao, Q, Wang, BG
Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. 2003;(9):654-7
Abstract
OBJECTIVE To evaluate the efficacy of Integrative Chinese and western medicine (ICWM) in treating SARS. METHODS By controlled paralled design, 49 patients of SARS were studied, they were divided into the control group (n = 29) and the ICWM group (n = 20). The former was treated according to the "Recommended Program for Treatment of SARS" provided by Health Ministry, by administering of such drugs as Ribavirin, Levofloxacin, Thymopentin, Azithromycin, etc, the latter was treated with the ICWM protocol for SARS of "Special Technological Action to Prevent and Treat SARS" provided by Science and Technology Ministry. RESULTS (1) The time for improving symptom in the ICWM group was 5.10 days and that in the control group was 7.62 days, the difference between them was significant (P < 0.05); (2) The days and amount for use hormone before subtract in the two group were similar, with insignificant difference (P > 0.05); (3) The days and amount for use hormone after subtract in the two groups were significantly different (P < 0.05); (4) The time for improving peripheral WBC count and absolute value of lymphocyte, as well as for absorption time of shadow in chest film were not different significantly between the two groups (P > 0.05). CONCLUSION In treating SARS, ICWM was superior to the treatment with western medicine alone in aspects of improving clinical symptom, promoting recovery of immune function and absorption of lung inflammation, decreasing the dosage of hormone used and shortening the therapeutic course.
-
7.
[Clinical observation on treatment for postoperative metastasis of gastric cancer by Jianpi Huoxue Jiedu prescription].
Xu, YQ, Xue, HN, Zhu, XQ, Chen, XD
Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine. 2003;(3):192-4
Abstract
OBJECTIVE To study the effect of Jianpi Huoxue Jiedu (JPHXJD) prescription on prevention of the postoperative metastasis of gastric cancer and to observe the changes of immunity and whole blood viscosity after treatment. METHODS JPHXJD prescription and chemotherapy were administered to the treated group for 12 successive months, while only chemotherapy was given to the control group. RESULTS The effective rate of anti-metastasis in the treated group was obviously better than that in the control group. In the aspects of enhancing Karnofsky scores, reducing whole blood viscosity and improving immunity after treatment, the treated group was better than the control group (P<0.05). CONCLUSION JPHXJD prescription combined with chemotherapy shows apparent effect on anti-metastasis. It can improve the quality of life of the patients, lower the whole blood viscosity and improve the immunity function.