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Associations of Coffee Drinking with Systemic Immune and Inflammatory Markers.
Loftfield, E, Shiels, MS, Graubard, BI, Katki, HA, Chaturvedi, AK, Trabert, B, Pinto, LA, Kemp, TJ, Shebl, FM, Mayne, ST, et al
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 2015;(7):1052-60
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Abstract
BACKGROUND Coffee drinking has been inversely associated with mortality as well as cancers of the endometrium, colon, skin, prostate, and liver. Improved insulin sensitivity and reduced inflammation are among the hypothesized mechanisms by which coffee drinking may affect cancer risk; however, associations between coffee drinking and systemic levels of immune and inflammatory markers have not been well characterized. METHODS We used Luminex bead-based assays to measure serum levels of 77 immune and inflammatory markers in 1,728 older non-Hispanic Whites. Usual coffee intake was self-reported using a food frequency questionnaire. We used weighted multivariable logistic regression models to examine associations between coffee and dichotomized marker levels. We conducted statistical trend tests by modeling the median value of each coffee category and applied a 20% false discovery rate criterion to P values. RESULTS Ten of the 77 markers were nominally associated (P trend < 0.05) with coffee drinking. Five markers withstood correction for multiple comparisons and included aspects of the host response namely chemotaxis of monocytes/macrophages (IFNγ, CX3CL1/fractalkine, CCL4/MIP-1β), proinflammatory cytokines (sTNFRII), and regulators of cell growth (FGF-2). Heavy coffee drinkers had lower circulating levels of IFNγ [odds ratios (OR), 0.35; 95% confidence intervals (CI), 0.16-0.75], CX3CL1/fractalkine (OR, 0.25; 95% CI, 0.10-0.64), CCL4/MIP-1β (OR, 0.48; 95% CI, 0.24-0.99), FGF-2 (OR, 0.62; 95% CI, 0.28-1.38), and sTNFRII (OR, 0.34; 95% CI, 0.15-0.79) than non-coffee drinkers. CONCLUSIONS Lower circulating levels of inflammatory markers among coffee drinkers may partially mediate previously observed associations of coffee with cancer and other chronic diseases. IMPACT Validation studies, ideally controlled feeding trials, are needed to confirm these associations.
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A tiered approach to assessing children's exposure: a review of methods and data.
Armstrong, TW, Zaleski, RT, Konkel, WJ, Parkerton, TJ
Toxicology letters. 2002;(1-3):111-9
Abstract
From a public health view, there are many important issues to improving children's and adolescent's health, for example, prenatal and childhood nutrition, immunizations, infectious disease control, and drug/alcohol/tobacco control. There has been increasing emphasis worldwide on protecting children from adverse health effects due to environmental factors, including chemicals. For well-studied contaminants (e.g. lead) the risks to children are reasonably known and appropriate risk management actions, in a public health context, can be undertaken. For a number of other chemicals, hazard and exposure data are less complete, and risk-based priorities are consequently less substantive. The US EPA's Voluntary Children's Chemical Evaluation Program proposal prompted additional efforts to develop and improve methods and data for assessing children's exposure. The goal is to efficiently identify the substances and conditions that present the highest potential risks to children, so that resources can be applied efficiently to assure their health improvement. The methods we illustrate use an iterative (tiered) approach for (a) screening level and (b) more detailed exposure assessments relevant to children. We also review and reference the key information sources available for such assessments and analyze the information and method's strengths and limitations.